Aclidinium Bromide

CAT#: H 314208

CAS#: 320345-99-1

Description: Aclidinium bromide is a long-acting anticholinergic bronchodilator approved by the FDA in 2012 for use in the management of chronic obstructive pulmonary disease (COPD) which includes chronic bronchitis and emphysema. It is not however used for acute exacerbations. Aclidinium bromide is an inhalation powder promoted by Forest Pharmaceuticals in the US under the trade name Tudorza Pressair. It is also manufactured and marketed by Menarini Pharmaceuticals in the EU under the trade name Bretaris Genuair, in the UK as Eklira Genuair and in the Canada as Tudorza Genuair.

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Synthetic Routes

Aclidinium Bromide - Synthetic Route 1

Aclidinium Bromide route01

Synthetic reference

Prat, Maria; Fernandez, Dolors; Buil, M. Antonia; Crespo, Maria I.; Casals, Gaspar; Ferrer, Manuel; Tort, Laia; Castro, Jordi; Monleon, Juan M.; Gavalda, Amadeu; Miralpeix, Montserrat; Ramos, Israel; Domenech, Teresa; Vilella, Dolors; Anton, Francisca; Huerta, Josep M.; Espinosa, Sonia; Lopez, Manuel; Sentellas, Sonia; Gonzalez, Marisa; Alberti, Joan; Segarra, Victor; Cardenas, Alvaro; Beleta, Jorge; Ryder, Hamish. Discovery of Novel Quaternary Ammonium Derivatives of (3R)-Quinuclidinol Esters as Potent and Long-Acting Muscarinic Antagonists with Potential for Minimal Systemic Exposure after Inhaled Administration: Identification of (3R)-3-{[Hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane Bromide (Aclidinium Bromide). Journal of Medicinal Chemistry. Volume 52. Issue 16. Pages 5076-5092. Journal. (2009).

Aclidinium Bromide - Synthetic Route 2

Aclidinium Bromide route02

Synthetic reference

Reddy, G. Nithun; Reddy, G. Samhitha; Reddy, G. Madaalasa; Ramani, M.; Reddy, G. Pratap. A process for preparing aclidinium bromide and intermediates thereof. Assignee GBR Laboratories Pvt. Ltd., India; Rachana Pharma Tech. IN 201741005254. (2018).

Aclidinium Bromide - Synthetic Route 3

Aclidinium Bromide route03

Synthetic reference

Huang, Heyi; Zhang, Xin; Tao, Yan; Zhou, Yingli; Jiang, Wenmin; Liu, Ying. high-purity and high-yield preparation method of Aclidinium bromide suitable for industrialized production. Assignee Guangzhou Maidakang Pharmaceutical Co., Ltd., Peop. Rep. China. CN 106831756. (2017).

Aclidinium Bromide - Synthetic Route 4

Aclidinium Bromide route04

Synthetic reference

Zhao, Shengyin; An, Yulong; Wang, Ming. Preparation method of choline M receptor antagonist Aclidinium bromide. Assignee Donghua University, Peop. Rep. China; Shanghai Fangyu Health Pharmaceutical Technology Co., Ltd. CN 105440030. (2016).