Stiripentol

CAT#: H330238

CAS#: 49763-96-4

Description: Stiripentol (marketed as Diacomit by Laboratoires Biocodex) is an anticonvulsant drug used in the treatment of epilepsy. It is approved for the treatment of Dravet syndrome, an epilepsy syndrome. Stiripentol increases GABAergic activity. At clinically relevant concentrations, it enhances central GABA neurotransmission through a barbiturate-like effect, since it increases the duration of opening of GABA-A receptor channels in hippocampal slices.

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Synthetic Routes

Stiripentol - Synthetic Route 1

Stiripentol route01

Synthetic reference

Hu, Aixi; Wu, Zhilin; Ye, Jiao. (Assignee Hunan University, Peop. Rep. China). Preparation method of stiripentol. CN 102690252. (2012).

Stiripentol - Synthetic Route 2

Stiripentol route02

Synthetic reference

Chang, Meng-Yang; Tsai, Chung-Yu; Wu, Ming-Hao. NBS-mediated cyclization of trans-cinnamic alcohols. Tetrahedron. Volume 69. Issue 31. Pages 6364-6370. Journal. 2013.

Stiripentol - Synthetic Route 3

Stiripentol route03

Synthetic reference

Han, Xing-Wang; Zhang, Tao; Zheng, Yan-Long; Yao, Wei-Wei; Li, Jiang-Fei; Pu, You-Ge; Ye, Mengchun; Zhou, Qi-Lin. Bronsted Acid Enabled Nickel-Catalyzed Hydroalkenylation of Aldehydes with Styrene and its Derivatives. Angewandte Chemie, International Edition. Volume 57. Issue 18. Pages 5068-5071. Journal. 2018.

Stiripentol - Synthetic Route 4

Stiripentol route04

Synthetic reference

Rao, Tadimeti; Zhang, Chengzhi. (Assignee Auspex Pharmaceuticals, Inc., USA). Preparation of deuterated stiripentol compounds as GABA aminotransferase inhibitors and/or GABA reuptake transporter. WO 2011011420. (2011).