Lumateperone

CAT#: H564760

CAS#: 313368-91-1

Description: ITI-722 is a first-in-class dual 5HT2A receptor antagonist and dopamine receptor phosphoprotein modulator (DPPM).

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Synthetic Routes

Lumateperone - Synthetic Route 1

Lumateperone route01

Synthetic reference

Li, Peng; Zhang, Qiang; Robichaud, Albert J.; Lee, Taekyu; Tomesch, John; Yao, Wei; Beard, J. David; Snyder, Gretchen L.; Zhu, Hongwen; Peng, Youyi; Hendrick, Joseph P.; Vanover, Kimberly E.; Davis, Robert E.; Mates, Sharon; Wennogle, Lawrence P. Discovery of a Tetracyclic Quinoxaline Derivative as a Potent and Orally Active Multifunctional Drug Candidate for the Treatment of Neuropsychiatric and Neurological Disorders. Journal of Medicinal Chemistry. Intra-Cellular Therapies, Inc. New York, USA 10032Volume 57. Issue 6. Pages 2670-2682. 2014.

Lumateperone - Synthetic Route 2

Lumateperone route02

Synthetic reference

Tomesch, John Charles; Li, Peng; Yao, Wei; Zhang, Qiang; Beard, James David; Thompson, Andrew S.; Cheng, Hua. Process for preparation of heterocycle fused gamma-carbolines Assignee Intra-Cellular Therapies, Inc., USA. 2008. WO 2008112280.

Lumateperone - Synthetic Route 3

Lumateperone route03

Synthetic reference

Robichaud, Albert J.; Lee, Taekyu; Deng, Wei; Mitchell, Ian S.; Haydar, Simon; Chen, Wenting; McClung, Christopher D.; Calvello, Emilie J. B.; Zawrotny, David M. Preparation of substituted heterocycle fused gamma-carbolines. Assignee Du Pont Pharmaceuticals Company, USA. 2000. WO 2000077010