Atomoxetine

CAT#: H593037

CAS#: 83015-26-3

Description: Atomoxetine is a selective inhibitor of noradrenaline reuptake; atomoxetine was originally called tomoxetine but changed to avoid any potential confusion with tamoxifen that might lead to errors in dispensing the drug.

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Synthetic Routes

Atomoxetine - Synthetic Route 1

Atomoxetine route01

Synthetic reference

Wickens, Zachary K.; Skakuj, Kacper; Morandi, Bill; Grubbs, Robert H. Catalyst-Controlled Wacker-Type Oxidation: Facile Access to Functionalized Aldehydes. Journal of the American Chemical Society. Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering. California Institute of Technology. Pasadena, USA 91125. Volume 136. Issue 3. Pages 890-893. 2014

Atomoxetine - Synthetic Route 2

Atomoxetine route02

Synthetic reference

Lifchits, Olga; Alberico, Dino; Zakharian, Irina; Charette, Andre B. Nucleophilic addition of phenol derivatives to methyl 1-nitrocyclopropanecarboxylates. Journal of Organic Chemistry. Department of Chemistry. Universite de Montreal. Montreal, Can. H3C 3J7. Volume 73. Issue 17. Pages 6838-6840. 2008

Atomoxetine - Synthetic Route 3

Atomoxetine route03

Synthetic reference

Bracher, Franz; Litz, Thomas. An efficient chemoenzymic route to the antidepressants (R)-fluoxetine and (R)-tomoxetine. Bioorganic & Medicinal Chemistry. Institut fur Pharmazeutische Chemie. Technischen Universitat Braunschweig. Braunschweig, Germany 38106. Volume 4.Issue 6. Pages 877-880. 1996

Atomoxetine - Synthetic Route 4

Atomoxetine route04

Synthetic reference

Li, Yang; Wang, Zheng; Ding, Kuiling. Minimizing Aryloxy Elimination in RhI-Catalyzed Asymmetric Hydrogenation of β-Aryloxyacrylic Acids using a Mixed-Ligand Strategy. Chemistry - A European Journal. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry. Chinese Academy of Sciences. Shanghai, Peop. Rep. China 200032. Volume 21. Issue 46. 2015

Atomoxetine - Synthetic Route 5

Atomoxetine route05

Synthetic reference

Trost, Barry M.; Fraisse, Pierre L.; Ball, Zachary T. A stereospecific ruthenium-catalyzed allylic alkylation. Angewandte Chemie, International Edition. Department of Chemistry. Stanford University. Stanford, USA 94305-5080. Volume 41. Issue 6. Pages 1059-1061. 2002

Atomoxetine - Synthetic Route 6

Atomoxetine route06

Synthetic reference

Vogl, Michael; Kratzer, Regina; Nidetzky, Bernd; Brecker, Lothar. Candida tenuis Xylose Reductase Catalyzed Reduction of Aryl Ketones for Enantioselective Synthesis of Active Oxetine Derivatives. Chirality. Department of Organic Chemistry. University of Vienna. Vienna, Austria.Volume 24. Issue 10. Pages 847-853. 2012

Atomoxetine - Synthetic Route 7

Atomoxetine route07

Synthetic reference

Rej, Rohan Kalyan; Das, Tapas; Hazra, Suman; Nanda, Samik. Chemoenzymatic asymmetric synthesis of fluoxetine, atomoxetine, nisoxetine, and duloxetine. Tetrahedron: Asymmetry. Department of chemistry. Indian Institute of Technology. Kharagpur, India 721302. Volume 24. Issue 15-16. Pages 913-918. 2013

Atomoxetine - Synthetic Route 8

Atomoxetine route08

Synthetic reference

Xu, Cheng-Fu; Yuan, Cheng-Ye. An improved method for the synthesis of optically active tomoxetines and fluoxetines. Chinese Journal of Chemistry. Volume 22. Issue 8. Pages 775-778. 2004 Shanghai Institute of Organic Chemistry. Chinese Academy of Sciences. Shanghai, Peop. Rep. China 200032.

Atomoxetine - Synthetic Route 9

Atomoxetine route09

Synthetic reference

Liu, Hui-Ling; Hoff, Bard Helge; Anthonsen, Thorleif. Chemoenzymatic synthesis of the non-tricyclic antidepressants Fluoxetine, Tomoxetine and Nisoxetine. Perkin 1. Department of Chemistry. Norwegian University of Science and Technology. Trondheim, Norway N-7491. Issue 11. Pages 1767-1769. 2000

Atomoxetine - Synthetic Route 10

Atomoxetine route010

Synthetic reference

Srinivasan, Chidambaram Venkateswaran; Johar, Perminder Singh; Wadhwa, Lalit. An improved process for synthesizing highly pure atomoxetine. Assignee Ind-Swift Laboratories Limited, India. IN 2008DE01002. 2009