Gadobutrol

CAT#: H314223

CAS#: 138071-82-6

Description: Gadobutrol is a gadolinium-based MRI contrast agent (GBCA). It received marketing approval in Canada and in the United States. As of 2007, it was the only GBCA approved at 1.0 molar concentrations. Gadobutrol is marketed by Bayer Schering Pharma as Gadovist, and by Bayer HealthCare Pharmaceuticals as Gadavist.

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Synthetic Routes

Gadobutrol - Synthetic Route 1

Gadobutrol route01

Synthetic reference

Wang, Chungui; Guo, Shuai; Zhang, Xuyang; Huo, Xianghong; Wang, Qi; Wang, Lichun; Wang, Jingyi. Method for preparing gadobutrol. Assignee Tianjin Kelun Pharmaceutical Research Co., Ltd., Peop. Rep. China; Sichuan Kelun Pharmaceutical Research Co., Ltd. CN 109293592. (2019).

Gadobutrol - Synthetic Route 2

Gadobutrol route02

Synthetic reference

Long, Xiangtian; Tan, Junrong; Lu, Biao; Lai, Yingjie; Liang, Long; Xie, Dexun. Method for preparing high purity Gadobutrol. Assignee Chem-Stone Co., Ltd., Peop. Rep. China. CN 108299322. (2018).

Gadobutrol - Synthetic Route 3

Gadobutrol route03

Synthetic reference

Long, Xiangtian; Zhou, Lei; Lai, Yingjie; Bai, Libin; Cao, Benwen; Tan, Junrong; Liang, Long; Xie, Dexun. Method for preparing high-yield gadobutrol using tetraazacyclododecane monoformaldehyde. Assignee Chem-Stone Co., Ltd., Peop. Rep. China. CN 108047151. (2018).

Gadobutrol - Synthetic Route 4

Gadobutrol route04

Synthetic reference

Yuan, Jinqiao; Zhu, Laifa; Liu, Hu. Preparation method of high-purity gadobutrol. Assignee Jiashi (Hunan) Pharmaceutical Technology Co., Ltd., Peop. Rep. China. CN 106543094. (2017).

Gadobutrol - Synthetic Route 5

Gadobutrol route05

Synthetic reference

Zhu, Quan; Shi, Xinghua; Zheng, Zhaoguang; Ou, Xiaomin; Tang, Dan; Wang, Rushang; Gu, Fei; He, Bao; Duan, Tingting; Cheng, Huiquan; Huang, Xiaoling; Huang, Yunbin; Huang, Yanxia; Chen, Yuling. Method for preparing contrast agents for magnetic resonance imaging. Assignee Guangzhou Consun Pharmaceutical Research Co., Ltd., Peop. Rep. China. CN 102399199. (2012).

Gadobutrol - Synthetic Route 6

Gadobutrol route06

Synthetic reference

Argese, Maria; Ripa, Giorgio. Preparation of 1,4,7,10-tetraazabicyclo[8.2.2]tetradecan-2-one for the preparation of tetraazamacrocycles. Assignee Bracco S.P.A., Italy; Dibra S.P.A. WO 9905145. (1999).