Rufinamide

CAT#: H300330

CAS#: 106308-44-5

Description: Rufinamide is a board spectrum anticonvulsant. It is used in combination with other medication and therapy to treat Lennox–Gastaut syndrome and various other seizure disorders. Rufinamide was approved by the US Food and Drug Administration on November 14, 2008 as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in children 4 years and older and adults. Rufinamide has efficacy for partial seizures. Rufinamide prolongs the inactivation of sodium channels and limits the frequency of action potential firing in cultured and acutely isolated neurons.

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Synthetic Routes

Rufinamide - Synthetic Route 1

Rufinamide route01

Synthetic reference

Zhang, Ping; Russell, M. Grace; Jamison, Timothy F. Continuous Flow Total Synthesis of Rufinamide. Organic Process Research & Development. Volume 18. Issue 11. Pages 1567-1570. 2014.

Rufinamide - Synthetic Route 2

Rufinamide route02

Synthetic reference

Singh, Kuldeep; Sarbajna, Abir; Dutta, Indranil; Pandey, Pragati; Bera, Jitendra K. Hemilability-Driven Water Activation: A NiII Catalyst for Base-Free Hydration of Nitriles to Amides. Chemistry - A European Journal. Volume 23. Issue 32. Pages 7761-7771. 2017.

Rufinamide - Synthetic Route 3

Rufinamide route03

Synthetic reference

Wang, Junmin; Jun, Changsoo; Chai, Kyuyun; Kwak, Kyungchell; Quan, Zheshan. Synthesis and anticonvulsant activity of 1-substituted benzyl N-substituted 1,2,3-triazole-4-carboxanilides. Progress in Natural Science. Volume 16. Issue 9. Pages 925-929. 2006.

Rufinamide - Synthetic Route 4

Rufinamide route04

Synthetic reference

Attolino, Emanuele; Colombo, Lino; Mormino, Ilaria; Allegrini, Pietro. Method for the preparation of rufinamide using 1,3-dipolar cycloaddition as the key step. Assignee Dipharma Francis S.r.l., Italy. US 20100234616. (2010).

Rufinamide - Synthetic Route 5

Rufinamide route05

Synthetic reference

Kankan, Rajendra Narayanrao; Rao, Dharmaraj Ramachandra; Birari, Dilip Ramdas. Process for preparation of rufinamide. Assignee CIPLA Limited, India. WO 2010043849. (2010).

Rufinamide - Synthetic Route 6

Rufinamide route06

Synthetic reference

Rajadhyaksha, Mangesh Narayan; Nair, Ranjeet; Ramesan, P. V.; Johnson, K.; Milind, Panandikar Aditi. Process for preparation of fluorinated triazole compound. Assignee Indoco Remedies Limited, India. IN 2010MU02477. (2013).

Rufinamide - Synthetic Route 7

Rufinamide route07

Synthetic reference

Davuluri, Ramamohan Rao; Ravi, Ponnaiah; Kumar, Dehury Sanjay; Selvaraju, K; Deepthi, V. P. S. S.; Naidu, S. Dhanunjaya. Improved process for the preparation of rufinamide. WO 2012025936. (2012).

Rufinamide - Synthetic Route 8

Rufinamide route08

Synthetic reference

Yadav, Dolly; Singh, Nem; Kim, Tae Wu; Kim, Jae Young; Park, No-Joong; Baeg, Jin-Ook. Highly regioselective and sustainable solar click reaction: a new post-synthetic modified triazole organic polymer as a recyclable photocatalyst for regioselective azide-alkyne cycloaddition reaction. Green Chemistry. Volume 21. Issue 10. Pages 2677-2685. 2019.

Rufinamide - Synthetic Route 9

Rufinamide route09

Synthetic reference

Yang, Cheng; Chen, Yue; Wang, Jinghan; Li, Yongtao; Bai, Cuigai. Improved process for synthesis of Rufinamide. Assignee Xu He (Tianjin) Limited Company of Medical Science and Technology, Peop. Rep. China; Tianjin International Joint Academy of Biotechnology & Medicine. CN 103539750. (2014).

Rufinamide - Synthetic Route 10

Rufinamide route010

Synthetic reference

Siyan, Rajinder Singh; Gohel, Sunilkumar Vinubhai; Aher, Yogesh Subhas; Bhise, Nandu Baban; Singh, Girij Pal. Process for preparation of rufinamide. Assignee Lupin Limited, India. IN 2012KO00027. (2013).