CAT#: H206535
CAS#: 1448169-71-8
Description: Futibatinib, also known as TAS-120 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor TAS-120 selectively and irreversibly binds to and inhibits FGFR, which may result in the inhibition of both the FGFR-mediated signal transduction pathway and tumor cell proliferation, and increased cell death in FGFR-overexpressing tumor cells. FGFR is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival and its expression is upregulated in many tumor cell types.
Therapeutic agent containing 3,5-disubstituted benzene alkynyl compound for FGFR inhibitor-resistant cancer
By: Sootome, Hiroshi
World Intellectual Property Organization, WO2015008844 A1 2015-01-22
Preparation of 3,5-disubstituted alkynylbenzene compounds as FGFR inhibitors
By: Sagara, Takeshi; et al
World Intellectual Property Organization, WO2013108809 A1 2013-07-25