Rucaparib

CAT#: H100947

CAS#: 283173-50-2

Description: Rucaparib is a tricyclic indole poly(ADP-Ribose) polymerase (PARP1) inhibitor with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Rucaparib selectively binds to PARP1 and inhibits PARP1-mediated DNA repair, thereby enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis.

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Synthetic Routes

Rucaparib - Synthetic Route 1

Rucaparib route01

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Rucaparib - Synthetic Route 2

Rucaparib route02

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Rucaparib - Synthetic Route 3

Rucaparib route03

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Rucaparib - Synthetic Route 4

Rucaparib route04

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Rucaparib - Synthetic Route 5

Rucaparib route05

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Gillmore, Adam T.; Badland, Matthew; Crook, Clare L.; Castro, Nieves M.; Critcher, Douglas J.; Fussell, Steven J.; Jones, Katherine J.; Jones, Matthew C.; Kougoulos, Eleftherios; Mathew, Jinu S.; McMillan, Lynne; Pearce, John E.; Rawlinson, Fiona L.; Sherlock, Alexandra E.; Walton, Robert. Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor. Organic Process Research & Development. Volume 16. Issue 12. Pages 1897-1904. 2012.

Rucaparib - Synthetic Route 6

Rucaparib route06

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Alluri, Santosh R.; Riss, Patrick J. Poly(ADP-ribose) Polymerase in Neurodegeneration: Radiosynthesis and Radioligand Binding in ARC-SWE tg Mice. ACS Chemical Neuroscience. Volume 9. Issue 6. Pages 1259-1263. 2018.

Rucaparib - Synthetic Route 7

Rucaparib route07

Synthetic reference

Yan, Libo; Deng, Haicun; Jin, Yonghua; Liu, Yu. Preparation of rucaparib for the treatment of ovarian cancer. Assignee Jiangsu Kaiyuan Pharmaceutical Co., Ltd., Peop. Rep. China. CN 109824677 A. (2019).