Selexipag

CAT#: H317125

CAS#: 475086-01-2

Description: Selexipag, also known as ACT-293987 and NS-304, is a a first-in-class orally available selective non-prostanoid IP receptor agonist, which is currently in development by Actelion as a treatment of pulmonary arterial hypertension. Selexipag and its active metabolite, ACT-333679, are agonists at the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation.

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Asaki, Tetsuo; Hamamoto, Taisuke; Sugiyama, Yukiteru; Kuwano, Keiichi; Kuwabara, Kenji. Structure-activity studies on diphenylpyrazine derivatives: A novel class of prostacyclin receptor agonists. Bioorganic & Medicinal Chemistry. Volume 15. Issue 21. Pages 6692-6704. 2007.