WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130128
CAS#: 2765264-50-2
Description: JNJ-6204 is a dual inhibitor of CSNK1D (IC50 = 2.3 nM) and CSNK1E (IC50 = 137 nM).
Hodoodo Cat#: H130128
Name: JNJ-6204
CAS#: 2765264-50-2
Chemical Formula: C19H11D6FN6O
Exact Mass: 370.18
Molecular Weight: 370.420
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 61.61; H, 6.26; F, 5.13; N, 22.69; O, 4.32
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Synonym: JNJ-6204; JNJ6204; JNJ 6204
IUPAC/Chemical Name: 2-(5-fluoropyridin-2-yl)-6,6-bis(methyl-d3)-3-(1H-pyrazolo[3,4-b]pyridin-4-yl)-6,7-dihydro-4H-pyrazolo[5,1-c][1,4]oxazine
InChi Key: WZMIWVZGYMKUDV-WFGJKAKNSA-N
InChi Code: InChI=1S/C19H17FN6O/c1-19(2)10-26-15(9-27-19)16(12-5-6-21-18-13(12)8-23-24-18)17(25-26)14-4-3-11(20)7-22-14/h3-8H,9-10H2,1-2H3,(H,21,23,24)/i1D3,2D3
SMILES Code: [2H]C(C(OC1)(C([2H])([2H])[2H])CN2C1=C(C3=C4C(NN=C4)=NC=C3)C(C5=NC=C(F)C=C5)=N2)([2H])[2H]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Increased CSNK1D expression/activity plays an important role in the pathology of certain cancers, metabolic processes, neurodegenerative diseases, and mood/psychiatric disorders.
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 370.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. https://patents.google.com/patent/WO2022058920A1/en
2. https://www.eubopen.org/sites/www.eubopen.org/files/chemical-probes/EUbOPEN_ProbeSheet_JNJ-6204_v1.pdf