WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130196
CAS#: 1672691-50-7
Description: JZP-MA-11 is the first PET ligand targeting the endocannabinoid α/β-hydrolase domain 6 (ABHD6) in vivo. JZP-MA-11 shows promise in the development of a greater understanding of the role of ABHD6 in peripheral and CNS disorders.
Hodoodo Cat#: H130196
Name: JZP-MA-11
CAS#: 1672691-50-7
Chemical Formula: C15H17FN4O2S
Exact Mass: 336.11
Molecular Weight: 336.390
Elemental Analysis: C, 53.56; H, 5.09; F, 5.65; N, 16.66; O, 9.51; S, 9.53
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Synonym: JZP-MA-11; JZP MA 11; JZP MA-11; JZP-MA 11
IUPAC/Chemical Name: 4-(piperidin-1-yl)-1,2,5-thiadiazol-3-yl (4-fluorophenyl)(methyl)carbamate
InChi Key: NLWSYKNCVGFXOV-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H17FN4O2S/c1-19(12-7-5-11(16)6-8-12)15(21)22-14-13(17-23-18-14)20-9-3-2-4-10-20/h5-8H,2-4,9-10H2,1H3
SMILES Code: O=C(OC1=NSN=C1N2CCCCC2)N(C3=CC=C(F)C=C3)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 336.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Mardon K, Patel JZ, Savinainen JR, Stimson DHR, Oyagawa CRM, Grimsey NL, Migotto MA, Njiru GFM, Hamilton BR, Cowin G, Yli-Kauhaluoma J, Vanduffel W, Blakey I, Bhalla R, Cawthorne C, Celen S, Bormans G, Thurecht KJ, Ahamed M. Utilizing PET and MALDI Imaging for Discovery of a Targeted Probe for Brain Endocannabinoid α/β-Hydrolase Domain 6 (ABHD6). J Med Chem. 2023 Jan 12;66(1):538-552. doi: 10.1021/acs.jmedchem.2c01485. Epub 2022 Dec 14. PMID: 36516997.