WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130221
CAS#: 937820-89-8
Description: JC2-11 is a pan-inflammasome inhibitor, with the potential to serve as a key agent in the treatment of certain cancers and metabolic disorders that are a result of dysregulated inflammasome activation. JC2-11 was found to inhibit both (IL)-1β and lactate dehydrogenases secretion, as well as caspase-1 activity.
Hodoodo Cat#: H130221
Name: JC2-11
CAS#: 937820-89-8
Chemical Formula: C17H15FO4
Exact Mass: 302.10
Molecular Weight: 302.300
Elemental Analysis: C, 67.54; H, 5.00; F, 6.28; O, 21.17
Synonym: JC2-11; JC211; JC2 11
IUPAC/Chemical Name: (E)-1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
InChi Key: YYAIFDXWRNNHAW-ZZXKWVIFSA-N
InChi Code: InChI=1S/C17H15FO4/c1-21-16-8-5-12(10-13(16)18)14(19)6-3-11-4-7-15(20)17(9-11)22-2/h3-10,20H,1-2H3/b6-3+
SMILES Code: O=C(C1=CC=C(OC)C(F)=C1)/C=C/C2=CC=C(O)C(OC)=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 302.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Lee G, Ahn H, Yun JH, Park J, Lee E, Oh S, Lee GS. JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022 Dec 28;12(1):22484. doi: 10.1038/s41598-022-27129-3. PMID: 36577816; PMCID: PMC9797494.
