WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130277
CAS#: N/A
Description: JR1-157 is a σ2R ligand that binds σ2R with a Ki of 47 nM. JR1-157 shows promise as a potential treatment for pancreatic cancer, as σ2R is often overexpressed in cancers, making it the ideal target for preventing/reducing tumor proliferation. JR1-157 was also found to increase the expression of LC3B.
Hodoodo Cat#: H130277
Name: JR1-157
CAS#: N/A
Chemical Formula: C23H29ClN6O
Exact Mass: 440.21
Molecular Weight: 440.980
Elemental Analysis: C, 62.65; H, 6.63; Cl, 8.04; N, 19.06; O, 3.63
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Synonym: JR1-157; JR1 157; NSC-807353; NSC807353; NSC 807353
IUPAC/Chemical Name: N-(5-chloroquinolin-8-yl)-5-((5-(diethylamino)pentan-2-yl)amino)pyrazine-2-carboxamide
InChi Key: KRUQRZWHJYOOJH-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H29ClN6O/c1-4-30(5-2)13-7-8-16(3)28-21-15-26-20(14-27-21)23(31)29-19-11-10-18(24)17-9-6-12-25-22(17)19/h6,9-12,14-16H,4-5,7-8,13H2,1-3H3,(H,27,28)(H,29,31)
SMILES Code: O=C(C1=NC=C(NC(CCCN(CC)CC)C)N=C1)NC2=C3N=CC=CC3=C(Cl)C=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 440.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Roy J, Kyani A, Hanafi M, Xu Y, Takyi-Williams J, Sun D, Osman EEA, Neamati N. Design and Synthesis of Orally Active Quinolyl Pyrazinamides as Sigma 2 Receptor Ligands for the Treatment of Pancreatic Cancer. J Med Chem. 2023 Feb 9;66(3):1990-2019. doi: 10.1021/acs.jmedchem.2c01769. Epub 2023 Jan 24. PMID: 36692906.