WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130442
CAS#: 2229068-13-5
Description: RasGRP3 ligand 96 is a ligand of Ras guanine-releasing protein 3 (RasGRP3) that displays higher selectivity for RasGRP3 as compared to PKC.
Hodoodo Cat#: H130442
Name: RasGRP3 ligand 96
CAS#: 2229068-13-5
Chemical Formula: C21H25NO5
Exact Mass: 371.17
Molecular Weight: 371.433
Elemental Analysis: C, 67.91; H, 6.78; N, 3.77; O, 21.54
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Synonym: RasGRP3 ligand 96
IUPAC/Chemical Name: (E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl pivalate
InChi Key: NMSQMKXWQOPPRS-NTEUORMPSA-N
InChi Code: InChI=1S/C21H25NO5/c1-20(2,3)19(25)26-13-21(12-23)10-14(18(24)27-21)9-15-11-22(4)17-8-6-5-7-16(15)17/h5-9,11,23H,10,12-13H2,1-4H3/b14-9+
SMILES Code: CC(C)(C)C(OCC(C/C1=C\C2=CN(C)C3=C2C=CC=C3)(CO)OC1=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 371.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Ann J, Czikora A, Saini AS, Zhou X, Mitchell GA, Lewin NE, Peach ML, Blumberg PM, Lee J. α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands. J Med Chem. 2018 Jul 26;61(14):6261-6276. doi: 10.1021/acs.jmedchem.8b00661. Epub 2018 Jul 3. PMID: 29860841.