WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130462
CAS#: N/A
Description: JH-LPH-50, an LpxH inhibitor, has the potential to play a key role in the development of antibiotics against Gram-negative pathogens. JH-LPH-50 achieves its antimicrobial activity by chelating the dimanganese cluster in the active site of LpxH.
Hodoodo Cat#: H130462
Name: JH-LPH-50
CAS#: N/A
Chemical Formula: C24H29ClF3N5O5S
Exact Mass: 591.15
Molecular Weight: 592.030
Elemental Analysis: C, 48.69; H, 4.94; Cl, 5.99; F, 9.63; N, 11.83; O, 13.51; S, 5.42
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Synonym: JH-LPH-50; JH LPH 50
IUPAC/Chemical Name: 6-(3-(4-((4-(3-chloro-5-(trifluoromethyl)phenyl)piperazin-1-yl)sulfonyl)phenyl)ureido)-N-hydroxyhexanamide
InChi Key: GMLRUFCQNBOXDH-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H29ClF3N5O5S/c25-18-14-17(24(26,27)28)15-20(16-18)32-10-12-33(13-11-32)39(37,38)21-7-5-19(6-8-21)30-23(35)29-9-3-1-2-4-22(34)31-36/h5-8,14-16,36H,1-4,9-13H2,(H,31,34)(H2,29,30,35)
SMILES Code: O=C(NO)CCCCCNC(NC1=CC=C(S(=O)(N2CCN(C3=CC(C(F)(F)F)=CC(Cl)=C3)CC2)=O)C=C1)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 592.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Kwak SH, Skyler Cochrane C, Cho J, Dome PA, Ennis AF, Kim JH, Zhou P, Hong J. Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH. ChemMedChem. 2023 Apr 4:e202300023. doi: 10.1002/cmdc.202300023. Epub ahead of print. PMID: 37014664.