WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130606
CAS#: JNJ-47909290
Description: JNJ-47909290 is a novel antagonist of CCR2.
Hodoodo Cat#: H130606
Name: JNJ-47909290
CAS#: JNJ-47909290
Chemical Formula: C23H30F3N3O4
Exact Mass: 469.22
Molecular Weight: 469.510
Elemental Analysis: C, 58.84; H, 6.44; F, 12.14; N, 8.95; O, 13.63
This product is not in stock, which may be available by custom synthesis.
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Synonym: JNJ 47909290, JNJ47909290, BDBM 50011986, BDBM-50011986
IUPAC/Chemical Name: ((3aS,5S,6aR)-5-((3S,4S)-3-Methoxytetrahydro-2H-pyran-4-ylamino)hexahydro-2H-cyclopenta[b]furan-3a-yl)(3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)methanone
InChi Key: QOVXPTCADXFNFV-NEHCWNBQSA-N
InChi Code: InChI=1S/C23H30F3N3O4/c1-31-19-13-32-6-3-18(19)28-16-9-20-22(10-16,4-7-33-20)21(30)29-5-2-17-14(12-29)8-15(11-27-17)23(24,25)26/h8,11,16,18-20,28H,2-7,9-10,12-13H2,1H3/t16-,18+,19-,20-,22-/m1/s1
SMILES Code: O=C([C@]1(C[C@H](N[C@@H]2[C@H](OC)COCC2)C3)[C@]3([H])OCC1)N4CC5=C(N=CC(C(F)(F)F)=C5)CC4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 469.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Winters MP, Teleha CA, Kang FA, McComsey D, O'Neill JC, Hou C, Kirchner T, Wang P, Johnson D, Sui Z. The discovery and SAR of cyclopenta[b]furans as inhibitors of CCR2. Bioorg Med Chem Lett. 2014 May 1;24(9):2137-40. doi: 10.1016/j.bmcl.2014.03.036. Epub 2014 Mar 22. PMID: 24685539.
