WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124695
CAS#: N/A
Description: Remiprostol (also known as SC-46275) is a potent, long-acting gastric antisecretory agent.
Hodoodo Cat#: H124695
Name: Remiprostol
CAS#: N/A
Chemical Formula: C25H36O5
Exact Mass: 416.26
Molecular Weight: 416.560
Elemental Analysis: C, 72.08; H, 8.71; O, 19.20
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Synonym: REMIPROSTOL; 110845-89-1; UNII-YCT6Z40PQR; Remiprostol; YCT6Z40PQR; SC-48834; SC-46275
IUPAC/Chemical Name: methyl (Z)-7-[(1R,2R,3R)-2-[(1E,5E)-6-(cyclopenten-1-yl)-4-hydroxy-4-methylhexa-1,5-dienyl]-3-hydroxy-5-oxocyclopentyl]hept-4-enoate
InChi Key: ZZVPHCPLTZTOBC-XBFCOAIZSA-N
InChi Code: InChI=1S/C25H36O5/c1-25(29,17-15-19-10-7-8-11-19)16-9-13-21-20(22(26)18-23(21)27)12-5-3-4-6-14-24(28)30-2/h3-4,9-10,13,15,17,20-21,23,27,29H,5-8,11-12,14,16,18H2,1-2H3/b4-3-,13-9+,17-15+/t20-,21-,23-,25?/m1/s1
SMILES Code: O=C(OC)CC/C=C\CC[C@@H]1[C@@H](/C=C/CC(C)(O)/C=C/C2=CCCC2)[C@H](O)CC1=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 416.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Perkins WE, Burton EG, Tsai BS, Collins PW, Casler JJ, Gasiecki AF, Bauer RF,
Jones PH, Gaginella TS. SC-46275: a potent, long-acting gastric antisecretory
prostaglandin with low oral bioavailability in the dog. J Pharmacol Exp Ther.
1991 Dec;259(3):1004-7. PMID: 1762057.
2: Savage MA, Moummi C, Karabatsos PJ, Lanthorn TH. SC-46275: a potent and
highly selective agonist at the EP3 receptor. Prostaglandins Leukot Essent Fatty
Acids. 1993 Dec;49(6):939-43. doi: 10.1016/0952-3278(93)90179-z. PMID: 8140121.
3: Tsai BS, Keith RH, Perkins WE, Walsh RE, Anglin CP, Collins PW, Gasiecki AW,
Bauer RF, Jones PH, Gaginella TS. Preferential binding of the novel
prostaglandin SC-46275 to canine gastric versus intestinal receptors. J
Pharmacol Exp Ther. 1995 Oct;275(1):368-73. PMID: 7562572.
4: Widomski D, Fretland DJ, Gasiecki AF, Collins PW. The prostaglandin analogs,
misoprostol and SC-46275, potently inhibit cytokine release from activated human
monocytes. Immunopharmacol Immunotoxicol. 1997 May;19(2):165-74. doi:
10.3109/08923979709007656. PMID: 9130003.
