WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124728
CAS#: 547731-67-9
Description: BCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis.
Hodoodo Cat#: H124728
Name: BCPA
CAS#: 547731-67-9
Chemical Formula: C22H22Cl2N2O2
Exact Mass: 416.11
Molecular Weight: 417.330
Elemental Analysis: C, 63.32; H, 5.31; Cl, 16.99; N, 6.71; O, 7.67
Synonym: BCPA; BCP A; BC PA
IUPAC/Chemical Name: (2E,2'E)-N,N'-(butane-1,4-diyl)bis(3-(2-chlorophenyl)acrylamide)
InChi Key: KHDKYKZKDQMAKP-PHEQNACWSA-N
InChi Code: InChI=1S/C22H22Cl2N2O2/c23-19-9-3-1-7-17(19)11-13-21(27)25-15-5-6-16-26-22(28)14-12-18-8-2-4-10-20(18)24/h1-4,7-14H,5-6,15-16H2,(H,25,27)(H,26,28)/b13-11+,14-12+
SMILES Code: O=C(NCCCCNC(/C=C/C1=C(Cl)C=CC=C1)=O)/C=C/C2=C(Cl)C=CC=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 417.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Cho E, Lee JK, Lee JY, Chen Z, Ahn SH, Kim ND, Kook MS, Min SH, Park BJ, Lee
TH. BCPA {N,N'-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]}
Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-
Prolyl cis-trans Isomerase Never in Mitosis A-Interacting 1. Int J Mol
Sci. 2018 Nov 1;19(11):3436. doi: 10.3390/ijms19113436. PMID: 30388885; PMCID:
PMC6275020.
2: Garcia EC, Anderson MS, Hagar JA, Cotter PA. Burkholderia BcpA mediates
biofilm formation independently of interbacterial contact-dependent growth
inhibition. Mol Microbiol. 2013 Sep;89(6):1213-25. doi: 10.1111/mmi.12339. Epub
2013 Aug 16. PMID: 23879629; PMCID: PMC3786370.
3: Budzik JM, Oh SY, Schneewind O. Cell wall anchor structure of BcpA pili in
Bacillus anthracis. J Biol Chem. 2008 Dec 26;283(52):36676-86. doi:
10.1074/jbc.M806796200. Epub 2008 Oct 21. PMID: 18940793; PMCID: PMC2605976.
4: Liang F, Senzaki H, Yin Z, Fan Y, Sughimoto K, Liu H. Transient hemodynamic
changes upon changing a BCPA into a TCPC in staged Fontan operation: a
computational model study. ScientificWorldJournal. 2013 Nov 10;2013:486815. doi:
10.1155/2013/486815. PMID: 24319371; PMCID: PMC3844169.