WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124991
CAS#: N/A
Description: JH-XII-03-02 is a PROTAC targeting LRRK2. JH-XII-03-0 displayed high potency and remarkable selectivity for LRKK2 when assessed in a of 468 panel kinases and serves the dual purpose of eliminating both the kinase activity as well as the scaffolding function of LRRK2.
Hodoodo Cat#: H124991
Name: JH-XII-03-02
CAS#: N/A
Chemical Formula: C24H31N3O9
Exact Mass: 505.21
Molecular Weight: 505.520
Elemental Analysis: C, 57.02; H, 6.18; N, 8.31; O, 28.48
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Synonym: JH-XII-0302; JH-XII 03-02; JH XII-03-02;
IUPAC/Chemical Name: 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12-tetraoxapentadecan-15-al
InChi Key: WKUFZEGOXKUHEE-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H31N3O9/c28-8-2-9-33-11-13-35-15-16-36-14-12-34-10-7-25-18-4-1-3-17-21(18)24(32)27(23(17)31)19-5-6-20(29)26-22(19)30/h1,3-4,8,19,25H,2,5-7,9-16H2,(H,26,29,30)
SMILES Code: O=C(CC1)NC(C1N2C(C3=CC=CC(NCCOCCOCCOCCOCCC=O)=C3C2=O)=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 505.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Hatcher JM, Zwirek M, Sarhan AR, Vatsan PS, Tonelli F, Alessi DR, Davies P, Gray NS. Development of a highly potent and selective degrader of LRRK2. Bioorg Med Chem Lett. 2023 Oct 1;94:129449. doi: 10.1016/j.bmcl.2023.129449. Epub 2023 Aug 15. PMID: 37591317.