WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H592589
CAS#: 32953-89-2
Description: Rimiterol is a beta 2 stimulant, therefore affects the cardiovascular system less than isoproterenol, but its action is of shorter duration than that of albuterol.
Hodoodo Cat#: H592589
Name: Rimiterol
CAS#: 32953-89-2
Chemical Formula: C12H17NO3
Exact Mass: 223.12
Molecular Weight: 223.272
Elemental Analysis: C, 64.55; H, 7.67; N, 6.27; O, 21.50
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Synonym: Rimiterol
IUPAC/Chemical Name: 1,2-Benzenediol, 4-(hydroxy-2-piperidinylmethyl)-, (R*,S*)-
InChi Key: IYMMESGOJVNCKV-JOYOIKCWSA-N
InChi Code: InChI=1S/C12H17NO3/c14-10-5-4-8(7-11(10)15)12(16)9-3-1-2-6-13-9/h4-5,7,9,12-16H,1-3,6H2/t9-,12+/m0/s1
SMILES Code: OC1=CC=C([C@@H](O)[C@H]2NCCCC2)C=C1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 223.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Marlin GE, Turner P. Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. Br J Clin Pharmacol. 1975 Feb;2(1):41-8. PubMed PMID: 10940; PubMed Central PMCID: PMC1402492.
2: Marlin GE, Turner P. The relative potencies and beta2-selectivities of intravenous rimiterol, salbutamol and isoprenaline in asthmatic patients. Int J Clin Pharmacol Biopharm. 1975 Jul;12(1-2):158-69. PubMed PMID: 240780.
3: Phillips PJ, Vedig AE, Jones PL, Chapman MG, Collins M, Edwards JB, Smeaton TC, Duncan BM. Metabolic and cardiovascular side effects of the beta 2-adrenoceptor agonists salbutamol and rimiterol. Br J Clin Pharmacol. 1980 May;9(5):483-91. PubMed PMID: 6104976; PubMed Central PMCID: PMC1429961.
4: Paterson IC, Willey RF, Shotter MV, Crompton GK. Further studies of rimiterol and salbutamol administered by intermittent positive-pressure ventilation, and an important observation on the technique of using the Bennett ventilator. Br J Clin Pharmacol. 1977 Oct;4(5):605-9. PubMed PMID: 20919; PubMed Central PMCID: PMC1429151.
5: Morton AR, Scott CA, Fitch KD. Rimiterol and the prevention of exercise-induced asthma. J Allergy Clin Immunol. 1989 Jan;83(1):61-5. PubMed PMID: 2563270.
6: Tarala RA, Martyn V, Paterson JW. Effect of intravenous injection of rimiterol in asthma. Br J Clin Pharmacol. 1981 Sep;12(3):333-40. PubMed PMID: 6117302; PubMed Central PMCID: PMC1401816.
7: Paterson IC, Willey RF, Shotter V, Grant IW, Crompton GK. Objective and subjective comparisons of terbutaline and rimiterol bronchodilator aerosols. Br J Dis Chest. 1975 Oct;69(0):267-72. PubMed PMID: 1106746.
8: Muittari A. A comparison of rimiterol and salbutamol by inhalation at high and low dose in asthmatic patients. Respiration. 1978;35(3):165-72. PubMed PMID: 25466.
9: Ydreborg SO, Svedmyr N, Thiringer G. Comparison of rimiterol and terbutaline, given by aerosol, in a long-term study. Scand J Respir Dis. 1977 Apr;58(2):117-24. PubMed PMID: 16339.
10: Bowman WC, Rodger IW. Actions of the sympathomimetic bronchodilator, rimiterol (R798), on the cardiovascular, respiratory and skeletal muscle systems of the anaesthetized cat. Br J Pharmacol. 1972 Aug;45(4):574-83. PubMed PMID: 5085231; PubMed Central PMCID: PMC1665966.
11: Cooke NJ, Kerr JA, Willey RF, Hoare MV, Grant IW, Cromptom GK. Response to rimiterol and salbutamol aerosols administered by intermittent positive-pressure ventilation. Br Med J. 1974 May 4;2(5913):250-2. PubMed PMID: 4597119; PubMed Central PMCID: PMC1610528.
12: Eriksson NE, Lindgren SB. The rapidity of bronchodilatation. A comparison of isoprenaline, terbutaline and rimiterol. Scand J Respir Dis. 1978 Feb;59(1):30-6. PubMed PMID: 26113.
13: Stephens JD, Hayward RP, Ead H, Adams L, Spurrell RA. Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline. Br J Clin Pharmacol. 1978 Aug;6(2):163-70. PubMed PMID: 28135; PubMed Central PMCID: PMC1429410.
14: Marlin GE, Hartnett BJ, Berend N. Comparative potencies and beta2-adrenoreceptor selectivities of rimiterol and salbutamol aerosols. Br J Clin Pharmacol. 1977 Feb;4(1):77-9. PubMed PMID: 14660; PubMed Central PMCID: PMC1428978.
15: Blackhall MI, Macartney B, O'Donnell SR. The acute effects of the administration of rimiterol aerosol in asthmatic children. Br J Clin Pharmacol. 1978 Jul;6(1):59-62. PubMed PMID: 27205; PubMed Central PMCID: PMC1429394.
16: Monie RD, Rocchiccioli KM, White JP. Sustained release aminophylline in asthma and its interaction with rimiterol. Br J Clin Pharmacol. 1982 Jul;14(1):110-2. PubMed PMID: 6125198; PubMed Central PMCID: PMC1427568.
17: Marlin GE, Turner P. Intravenous treatment with rimiterol and salbutamol in asthma. Br Med J. 1975 Jun 28;2(5973):715-9. PubMed PMID: 1139193; PubMed Central PMCID: PMC1673959.
18: Pinder RM, Brogden RN, Speight TM, Avery GS. Rimiterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1977 Aug;14(2):81-104. Review. PubMed PMID: 19226.
19: Bianco S, Kamburoff PL, Prime FJ. Comparison between the bronchodilator and cardiovascular effects of inhaling 0.5 mg. rimiterol ('Pulmadil') and 0.2 mg. salbutamol. Curr Med Res Opin. 1975;3(1):30-5. PubMed PMID: 1116382.
20: Pedersen JT. [Rimiterol (Pulmadil)]. Ugeskr Laeger. 1976 Nov 1;138(45):2816-7. Danish. PubMed PMID: 10658.