WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574016
CAS#: 7695-91-2
Description: (±)-α-Tocopherol acetate is the acetate form of (±)-α-tocopherol, a biologically active form of vitamin E. It prevents reductions in the percentage of embryos developing into blastocysts, levels of glutathione (GSH), and prevents increases in oxidative stress. (±)-α-Tocopherol acetate has been shown to prevent body weight loss and decreases in pulmonary dynamic compliance in mice exposed to sidestream cigarette smoke but not in sham exposure animals. However, it also increases the levels of IL-1β, IL-4, and IFN-γ in the bronchoalveolar lavage fluid (BALF) of sidestream cigarette-exposed, but not sham exposure, mice.
Hodoodo Cat#: H574016
Name: (±)-α-Tocopherol acetate
CAS#: 7695-91-2
Chemical Formula: C31H52O3
Exact Mass: 472.39
Molecular Weight: 472.750
Elemental Analysis: C, 78.76; H, 11.09; O, 10.15
Synonym: (±)-α-Tocopherol acetate, all-rac-α-Tocopherol Acetate, DL-α-Tocopherol Acetate, DL-Vitamin E acetate
IUPAC/Chemical Name: 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol, 6-acetate
InChi Key: ZAKOWWREFLAJOT-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3
SMILES Code: CC1=C2C(CCC(CCCC(C)CCCC(C)CCCC(C)C)(C)O2)=C(C)C(OC(C)=O)=C1C
Appearance: A liquid
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 472.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Sakamoto, N., Ozawa, M., Yokotani-Tomita, K., et al. DL-α-Tocopherol acetate mitigates maternal hyperthermia-induced pre-implantation embryonic death accompanied by a reduction of physiological oxidative stress in mice. Reproduction 135(4), 489-496 (2008).
2. Wang, S., Sun, N.N., Zhang, J., et al. Immunomodulatory effects of high-dose α-tocopherol acetate on mice subjected to sidestream cigarette smoke. Toxicology 175(1-3), 235-245 (2002).