WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574252
CAS#: 7616-22-0
Description: (±)-γ-Tocopherol is a form of vitamin E with antioxidant and anti-inflammatory properties. It traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays. It also reduces the synthesis of prostaglandin E2 (PGE2) induced by LPS in RAW 264.7 macrophages and by IL-1β in A549 cells. (±)-γ-Tocopherol inhibits LPS-induced nitrite release and inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells and reduces COX-2 activity in A549 cells pretreated with IL-1β. Serum levels of (±)-γ-tocopherol are decreased in patients with cardiovascular disease.
Hodoodo Cat#: H574252
Name: (±)-γ-Tocopherol
CAS#: 7616-22-0
Chemical Formula: C28H48O2
Exact Mass: 416.37
Molecular Weight: 416.690
Elemental Analysis: C, 80.71; H, 11.61; O, 7.68
Synonym: (±)-γ-Tocopherol, 7,8-Dimethyltocol, all-rac-γ-Tocopherol, DL-γ-Tocopherol
IUPAC/Chemical Name: 3,4-dihydro-2,7,8-trimethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
InChi Key: QUEDXNHFTDJVIY-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H48O2/c1-20(2)11-8-12-21(3)13-9-14-22(4)15-10-17-28(7)18-16-25-19-26(29)23(5)24(6)27(25)30-28/h19-22,29H,8-18H2,1-7H3
SMILES Code: OC1=CC(CCC(CCCC(CCCC(CCCC(C)C)C)C)(C)O2)=C2C(C)=C1C
Appearance: A solution in hexane
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 416.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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| In vivo protocol: |
1. Jiang, Q., Christen, S., Shigenaga, M.K., et al. γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. American Journal of Clinical Nutrition 74, 714-722 (2001).
2. Cooney, R.V., Franke, A.A., Harwood, P.J., et al. γ-Tocopherol detoxification of nitrogen dioxide: Superiority to α-tocopherol. Proceedings of the National Academy of Sciences of the United States of America 90, 1771-1775 (1993).
3. Jiang, Q., Elson-Schwab, I., Courtemanche, C., et al. γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences of the United States of America 97, 11494-11499 (2000).
