WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H462180
CAS#: 901787-88-0
Description: (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E and has anti-cancer activity.
Hodoodo Cat#: H462180
Name: (Z)-4EGI-1
CAS#: 901787-88-0
Chemical Formula: C18H12Cl2N4O4S
Exact Mass: 450.00
Molecular Weight: 451.278
Elemental Analysis: C, 47.91; H, 2.68; Cl, 15.71; N, 12.42; O, 14.18; S, 7.10
This product is not in stock, which may be available by custom synthesis.
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Synonym: (Z)-4EGI-1
IUPAC/Chemical Name: (Z)-2-(2-(4-(3,4-dichlorophenyl)thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid
InChi Key: KFRKRECSIYXARE-HMAPJEAMSA-N
InChi Code: InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14-
SMILES Code: O=C(O)/C(CC1=CC=CC=C1[N+]([O-])=O)=N\NC2=NC(C3=CC=C(Cl)C(Cl)=C3)=CS2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 451.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Takrouri K, Chen T, Papadopoulos E, et al. Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors. Eur J Med Chem. 2014;77:361‐377. doi:10.1016/j.ejmech.2014.03.034.
2: Mahalingam P, Takrouri K, Chen T, et al. Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J Med Chem. 2014;57(12):5094‐5111. doi:10.1021/jm401733v.
