WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574586
CAS#: 93879-40-4
Description: (±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol. (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol are inhibitors of the cytochrome P450 (CYP) isoform CYP2C19. (±)-N-3-Benzylnirvanol lowers plasma levels of cholesterol in mice.
Hodoodo Cat#: H574586
Name: (±)-N-3-Benzylnirvanol
CAS#: 93879-40-4
Chemical Formula: C18H18N2O2
Exact Mass: 294.14
Molecular Weight: 294.350
Elemental Analysis: C, 73.45; H, 6.16; N, 9.52; O, 10.87
Synonym: (±)-N-3-Benzylnirvanol
IUPAC/Chemical Name: 5-ethyl-5-phenyl-3-(phenylmethyl)-2,4-imidazolidinedione
InChi Key: ZMZDHUHMXXALFX-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H18N2O2/c1-2-18(15-11-7-4-8-12-15)16(21)20(17(22)19-18)13-14-9-5-3-6-10-14/h3-12H,2,13H2,1H3,(H,19,22)
SMILES Code: O=C1N(CC2=CC=CC=C2)C(C(C3=CC=CC=C3)(CC)N1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 294.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Suzuki, H., Kneller, M.B., Haining, R.L., et al. (+)-N-3-Benzyl-nirvanol and (−)-N-3-benzyl-phenobarbital: New potent and selective in vitro inhibitors of CYP2C19. Drug Metab. Dispos. 30(3), 235-239 (2002).
2. Maguire, J.H., Murthy, A.R., and Hall, I.H. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice. Eur. J. Pharmacol. 117(1), 135-138 (1985).
