WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H206211
CAS#: 286845-00-9
Description: ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis.
Hodoodo Cat#: H206211
Name: ABT-518
CAS#: 286845-00-9
Chemical Formula: C21H22F3NO8S
Exact Mass: 505.10
Molecular Weight: 505.460
Elemental Analysis: C, 49.90; H, 4.39; F, 11.28; N, 2.77; O, 25.32; S, 6.34
Synonym: ABT518; ABT 518; ABT-518.
IUPAC/Chemical Name: N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl)-N-hydroxyformamide
InChi Key: IVPPTWCRAFCOFJ-RTBURBONSA-N
InChi Code: InChI=1S/C21H22F3NO8S/c1-20(2)30-11-19(33-20)18(25(27)13-26)12-34(28,29)17-9-7-15(8-10-17)31-14-3-5-16(6-4-14)32-21(22,23)24/h3-10,13,18-19,27H,11-12H2,1-2H3/t18-,19-/m1/s1
SMILES Code: O=CN([C@@H]([C@@H]1OC(C)(C)OC1)CS(=O)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: ABT-518 is a potent inhibitor of gelatinase A and gelatinase B, two matrix metalloproteinase (MMP) enzymes involved in tumor growth and metastasis. ABT-518 has demonstrated robust antitumor activity in a variety of animal models. This compound is a potent and selective inhibitor of these enzyme targets.
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In vivo activity: |
The following data is based on the product molecular weight 505.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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