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Alpelisib

CAT# 204780
CAS# 1217486-61-7
Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Check for active clinical trials or closed clinical trials using this agent.
Synthetic Routes

Alpelisib

Synthetic Description

Furet, Pascal; Guagnano, Vito; Fairhurst, Robin A.; Imbach-Weese, Patricia; Bruce, Ian; Knapp, Mark; Fritsch, Christine; Blasco, Francesca; Blanz, Joachim; Aichholz, Reiner; Hamon, Jacques; Fabbro, Doriano; Caravatti, Giorgio Bioorganic & Medicinal Chemistry Letters Volume 23 Issue 13 Pages 3741-3748 Journal; Online Computer File 2013

Alpelisib

Synthetic Description

Gallou, Isabelle Sylvie; Gauer, Cornelius; Stowasser, Frank Assignee Novartis AG, Switz “Polymorphs of (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)pyridin-4-yl]thiazol-2-yl}amide” Dec 27, 2012 WO 2012175522 A1

Alpelisib

Synthetic Description

Erb, Bernhard; Gallou, Isabelle Sylvie; Kleinbeck, Florian Karl Assignee Novartis AG, Switz

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