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Adefovir Dipivoxil

CAT# 317160
CAS# 142340-99-6
Adefovir dipivoxil (trade names Preveon and Hepsera) is an antiviral acyclic nucleoside phosphonate (ANP) analog. It is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV). It is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) that works by blocking reverse transcriptase for the treatment of hepatitis B. Adefovir dipivoxil is not effective against HIV-1.
Synthetic Routes

Adefovir Dipivoxil-Route 01

Synthetic Reference

Roux, Loic; Priet, Stephane; Payrot, Nadine; Weck, Clement; Fournier, Maelenn; Zoulim, Fabien; Balzarini, Jan; Canard, Bruno; Alvarez, Karine. Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: Synthesis, antiviral activity and decomposition study. European Journal of Medicinal Chemistry. Volume 63. Pages 869-881. 2013.

Adefovir Dipivoxil-Route 02

Synthetic Reference

Yu, Richard H.; Schultze, Lisa M.; Rohloff, John C.; Dudzinski, Pawel W.; Kelly, Daphne E. Process Optimization in the Synthesis of 9-[2-(Diethylphosphonomethoxy)ethyl]adenine: Replacement of Sodium Hydride with Sodium tert-Butoxide as the Base for Oxygen Alkylation. Organic Process Research & Development. Volume 3. Issue 1. Pages 53-55. 1999.

Adefovir Dipivoxil-Route 03

Synthetic Reference

Wang, Xiao-qin; He, Ming-hua; Wang, Qin. Synthesis of 1,1'-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester (adefovir dipivoxil). Zhongguo Xinyao Zazhi. Volume 17. Issue 22. Pages 1937-1939. 2008.

Adefovir Dipivoxil-Route 04

Synthetic Reference

Liu, Ying; Wang, Decai. Synthesis of adefovir dipivoxil. Huagong Shikan. Volume 19. Issue 5. Pages 37-39.2005.

Adefovir Dipivoxil-Route 05

Synthetic Reference

Zhang, Yong; Li, Xin; Gong, Ping; Wang, Yumei. Synthesis of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) and its oral prodrug adefovir dipivoxil. Shenyang Yaoke Daxue Xuebao. Volume 18. Issue 2. Pages 95-97. 2001.

Adefovir Dipivoxil-Route 06

Synthetic Reference

Zhang, Sha; Li, Xiao-hong; Li, Yong-shu. Improvement on the synthesis of adefovir dipivoxil. Zhejiang Huagong. Volume 44. Issue 7. Pages 7-9. 2013.

Adefovir Dipivoxil-Route 07

Synthetic Reference

Arimilli, Murty N.; Kelly, Daphne E.; Lee, Thomas T. K.; Manes, Lawrence V.; Munger, John D.; Prisbe, Ernest J.; Schultze, Lisa M. Crystalline forms of adefovir dipivoxil. Assignee Gilead Sciences, Inc., USA. 2002.

Adefovir Dipivoxil-Route 08

Synthetic Reference

Lu, Min; Li, Zhongjing; Yuan, Hongyu; Lu, Xiulian; Du, Zhenxin. A preparation method of adefovir dipivoxil crystal substance. Assignee Cisen Pharmaceutical Co., Ltd., 2017.

Adefovir Dipivoxil-Route 09

Synthetic Reference

Hu, Xiaoxia; Chen, Tieqian. Method for synthesizing Adefovir Dipivoxil as anti-hepatitis B virus medicament. 2005.

Adefovir Dipivoxil-Route 10

Synthetic Reference

Hwang, Seong Gwan; Lee, Su Jin. Method for preparation of adefovir dipivoxil and its intermediate. Assignee Mirae Fine Chem Co., Ltd., S. Korea. 2010
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