Adefovir dipivoxil (trade names Preveon and Hepsera) is an antiviral acyclic nucleoside phosphonate (ANP) analog. It is a dipivoxil formulation of adefovir, a nucleoside reverse transcriptase inhibitor analog of adenosine with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV). It is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) that works by blocking reverse transcriptase for the treatment of hepatitis B. Adefovir dipivoxil is not effective against HIV-1.
Synthetic Routes
Adefovir Dipivoxil-Route 01
Synthetic Reference
Roux, Loic; Priet, Stephane; Payrot, Nadine; Weck, Clement; Fournier, Maelenn; Zoulim, Fabien; Balzarini, Jan; Canard, Bruno; Alvarez, Karine. Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: Synthesis, antiviral activity and decomposition study. European Journal of Medicinal Chemistry. Volume 63. Pages 869-881. 2013.
Adefovir Dipivoxil-Route 02
Synthetic Reference
Yu, Richard H.; Schultze, Lisa M.; Rohloff, John C.; Dudzinski, Pawel W.; Kelly, Daphne E. Process Optimization in the Synthesis of 9-[2-(Diethylphosphonomethoxy)ethyl]adenine: Replacement of Sodium Hydride with Sodium tert-Butoxide as the Base for Oxygen Alkylation. Organic Process Research & Development. Volume 3. Issue 1. Pages 53-55. 1999.
Zhang, Yong; Li, Xin; Gong, Ping; Wang, Yumei. Synthesis of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) and its oral prodrug adefovir dipivoxil. Shenyang Yaoke Daxue Xuebao. Volume 18. Issue 2. Pages 95-97. 2001.
Adefovir Dipivoxil-Route 06
Synthetic Reference
Zhang, Sha; Li, Xiao-hong; Li, Yong-shu. Improvement on the synthesis of adefovir dipivoxil. Zhejiang Huagong. Volume 44. Issue 7. Pages 7-9. 2013.
Adefovir Dipivoxil-Route 07
Synthetic Reference
Arimilli, Murty N.; Kelly, Daphne E.; Lee, Thomas T. K.; Manes, Lawrence V.; Munger, John D.; Prisbe, Ernest J.; Schultze, Lisa M. Crystalline forms of adefovir dipivoxil. Assignee Gilead Sciences, Inc., USA. 2002.
Adefovir Dipivoxil-Route 08
Synthetic Reference
Lu, Min; Li, Zhongjing; Yuan, Hongyu; Lu, Xiulian; Du, Zhenxin. A preparation method of adefovir dipivoxil crystal substance. Assignee Cisen Pharmaceutical Co., Ltd., 2017.
Adefovir Dipivoxil-Route 09
Synthetic Reference
Hu, Xiaoxia; Chen, Tieqian. Method for synthesizing Adefovir Dipivoxil as anti-hepatitis B virus medicament. 2005.
Adefovir Dipivoxil-Route 10
Synthetic Reference
Hwang, Seong Gwan; Lee, Su Jin. Method for preparation of adefovir dipivoxil and its intermediate. Assignee Mirae Fine Chem Co., Ltd., S. Korea. 2010