Skip to content
Hodoodo.comHodoodo.com

MedKoo Biosciences

Sales@hodoodo.com, Tel: +1 919-636-5577; Fax: +1 919-980-4831

  • Menu
  • Login / Register
    • No products in the cart.

  • Structure Search
  • Cart

    No products in the cart.

  • Home
  • Products
  • Drug Synthesis
  • Ordering
    • How to Order
    • Terms & Conditions
    • Privacy Policy
  • Services
    • Custom Synthesis
    • Technical Support
  • About Us
  • Contact Us
  • Resources
    • Hodoodo chemical nomenclature
    • Organic chemistry acronyms
    • Chemistry abbreviations and acronyms
    • NMR peaks of solvent residue

Acalabrutinib

CAT# 206112
CAS# 94898476-66
Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Synthetic Routes

Acalabrutinib - Synthetic route 1

Synthetic Description

Reference: Xu. X. (Suzhou Miracpharma); Process for the preparation of acalabrutinib. CN 107056786 (2017)

Acalabrutinib - Synthetic route 2

Synthetic Description

Reference:Mo, G.; Zha, X. (Suzhou Fushilai Pharmaceutical Co). Preparation of BTK inhibitor Acalabrutinib. CN 107522701 (2017)

Acalabrutinib - Synthetic route 3

Synthetic Description

Reference: Barf, TA.; Jans, CGM; De Man, APA; Oubrie, AA; Raaijmakers, HCA; Rewinkel, JBM;Sterrenburg, JG; Wijkmans, JCHM. Preparation of imidazopyrazinylbenzamide derivatives and analogs for use as Btk inhibitors. WO 2013010868 (2013).

Acalabrutinib-Route 04

Synthetic Reference

Anon. Process for preparation of 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide. IP.com Journal. Volume 19. Issue 4B. Pages 1-4. 2019.

Acalabrutinib-Route 05

Synthetic Reference

Wang, Peng; Li, Pixu; Gu, Xiangyong; Ge, Yadong; Wang, Zhong; Gao, Feng; Du, Qiangqiang. Processes for the preparation of acalabrutinib. WO 2019090269. 2019.

Acalabrutinib-Route 06

Synthetic Reference

Zheng, Xuchun; Zhang, Yiping; Fu, Chenchen. Synthesis method of acalabrutinib and its intermediate. Assignee Hangzhou Cheminspire Technologies Co., Ltd. CN 108250186. 2018.

Acalabrutinib-Route 07

Synthetic Reference

Hamdy, Ahmed; Rothbaum, Wayne; Izumi, Raquel; Lannutti, Brian; Covey, Todd; Ulrich, Roger; Johnson, Dave; Barf, Tjeerd; Kaptein, Allard. Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, a JAK-2 inhibitor, a PD-1 inhibitor and/or a PD-L1 inhibitor. Assignee Acerta Pharma B.V., Neth. WO 2016024228. 2016.

Acalabrutinib-Route 08

Synthetic Reference

Wu, Xueping; Chu, Yijie; Chen, Yao; Wang, Min. Method for preparing acalabrutinib as anti-leukemia drug using 4-aldehyde-N-2-pyridine-benzamide. Assignee Anqing CHICO Pharmaceutical Co., Ltd. CN 109020977. 2018.

Acalabrutinib-Route 09

Synthetic Reference

Bodhuri, Prabhudas; Gorin, Boris; Green, Melanie R. A.; Weeratunga, Gamimi. Processes for the preparation of Acalabrutinib and intermediates thereof. Assignee Apotex Inc.WO 2018191815. 2018.
Support
  • Tel: +1 919-636-5577
  • Fax: +1 919-980-4831
  • Email: Sales@hodoodo.com

Products
  • Latest Products
  • Featured Product
  • Products Categories

Stay In Touch
MedKoo Biosciences @ 2021 All Rights Reserved. 网站设计VcuSoft
  • Home
  • Products
  • Drug Synthesis
  • Ordering
    • How to Order
    • Terms & Conditions
    • Privacy Policy
  • Services
    • Custom Synthesis
    • Technical Support
  • About Us
  • Contact Us
  • Resources
    • Hodoodo chemical nomenclature
    • Organic chemistry acronyms
    • Chemistry abbreviations and acronyms
    • NMR peaks of solvent residue
  • Newsletter
  • [wcas-search-form]

Login

Lost your password?

Register

Your personal data will be used to support your experience throughout this website, to manage access to your account, and for other purposes described in our privacy policy.