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Alfuzosin Hydrochloride

CAT# 317165
CAS# 81403-68-1
Alfuzosin HCl is a pharmaceutical drug of the alpha-1 blocker class. As an antagonist of the alpha-1 adrenergic receptor, it works by relaxing the muscles in the prostate and bladder neck, making it easier to urinate. It is thus used to treat benign prostatic hyperplasia (BPH). Alfuzosin is marketed in the United States by Sanofi Aventis under the brand name Uroxatral and elsewhere under the tradename Xat or Xatral, and in Egypt under name of Prostetrol. Alfuzosin was approved by the FDA for treatment of BPH in June 2003.
Synthetic Routes

Alfuzosin HCl-Route 01

Synthetic Reference

Manoury, Philippe M.; Binet, Jean L.; Dumas, Andre P.; Lefevre-Borg, Francoise; Cavero, Icilio. Synthesis and antihypertensive activity of a series of 4-amino-6,7-dimethoxyquinazoline derivatives. Journal of Medicinal Chemistry. Volume 29. Issue 1. Pages 19-25. 1986.

Alfuzosin HCl-Route 02

Synthetic Reference

Zhu, Xingyan; Wang, Yanyan; Di, Yan; Jiang, Fang; Xu, Youjun. Improved synthesis of alfuzosin hydrochloride. Zhongguo Yaowu Huaxue Zazhi. Volume 19. Issue 5. Pages 352-355. 2009.

Alfuzosin HCl-Route 03

Synthetic Reference

Zhang, Zhiyong. Synthesis of Alfuzosin hydrochloride. Zhongguo Yiyao Gongye Zazhi. Volume 32. Issue 7. Pages 289-291. 2001

Alfuzosin Hydrochloride-Route 04

Synthetic Reference

Xu, Jing; He, Zhan; Song, Hongrui. Improved synthesis of alfuzosin hydrochloride. Jingxi Huagong Zhongjianti. Volume 40. Issue 3. Pages 40-43. 2010.

Alfuzosin HCl-Route 05

Synthetic Reference

Chen, Xian; Zhang, Qi; Li, Ying; Shi, Daxin; Li, Jiarong. An improved synthesis method of alfuzosin hydrochloride. Jingxi Huagong. Volume 28. Issue 7. Pages 710-713. 2011.

Alfuzosin HCl-Route 06

Synthetic Reference

Wang, Haiyan; Luo, Wengong; Zhang, Lulu. Improved process for preparing Alfuzosin hydrochloride. Assignee Liaoning Keji Pharmaceutical Co., Ltd., 2018.

Alfuzosin HCl-Route 07

Synthetic Reference

Keshav, Deo; Sanjay, Desai; Mohansihn, Rathod Dhiraj; Chandrakant, Parikh Chirag; Kantibhai, Patel Ripalkumar; Suresh, Mistry Chirayu. A process for the preparation of alfuzosin hydrochloride. Assignee Alembic Limited, India. 2010.

Alfuzosin HCl-Route 08

Synthetic Reference

Zhang, Peng. Process for preparing Alfuzosin hydrochloride. Assignee Liaoning Keji Pharmaceutical Co., Ltd. 2017.

Alfuzosin HCl-Route 09

Synthetic Reference

Li, Jiarong; Shi, Daxin; Chen, Xian; Zhang, Qi; Li, Ying. Method for preparation of Alfuzosin hydrochloride. Assignee Beijing Institute of Technology. 2010.

Alfuzosin HCl-Route 10

Synthetic Reference

Sadanand, Nadkarni Sunil; Bhivsan, Ahire Prakash; Chandrakantrao, Joshi Uday. Preparation of alfuzosin. Assignee Torrent Pharmaceuticals Limited. 2007.
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