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Almotriptan Malate

CAT# 317170
CAS# 181183-52-8
Almotriptan Malate is a triptan drug discovered and developed by Almirall for the treatment of heavy migraine headache. Almotriptan is a Serotonin-1b and Serotonin-1d Receptor Agonist. Binding of the drug to the receptor leads to vasoconstriction of the cranial blood vessels and thus affects the redistribution of cranial blood flow. Almotriptan significantly increases cerebral blood flow and reduces blood flow through extracerebral cranial vessels. Even though it affects cranial blood vessels a single dose of almotriptan (12.5 mg) has no clinically significant effect on blood pressure or heart rate in both young and elderly healthy volunteers.
Synthetic Routes

Almotriptan-Route 01

Synthetic Reference

Chen, Dongsheng; Chen, Yuanyuan; Ma, Zhilong; Zou, Lei; Li, Jianqi; Liu, Yu. One-Pot Synthesis of Indole-3-acetic Acid Derivatives through the Cascade Tsuji-Trost Reaction and Heck Coupling. Journal of Organic Chemistry. Volume 83. Issue 12. Pages 6805-6814. 2018.

Almotriptan-Route 02

Synthetic Reference

Bosch, J.; Roca, T.; Armengol, M.; Fernandez-Forner, D. Synthesis of 5-(sulfamoylmethyl)indoles. Tetrahedron. Volume 57. Issue 6. Pages 1041-1048. 2001.

Almotriptan-Route 03

Synthetic Reference

Li, Xiaolong; Qiu, Rui; Wan, Weili; Cheng, Xu; He, Yi; Hai, Li; Wu, Yong. Synthesis of 5-(Sulfamoylmethyl)indoles by Mild Negishi Coupling and Their Application in Almotriptan. Chemical Research in Chinese Universities. Volume 31. Issue 4. Pages 539-542. 2015.

Almotriptan-Route 04

Synthetic Reference

Lv, Shaobo. Process for preparation of Almotriptan. Assignee Stone Lake Pharma Tech Co., Ltd. 2014.

Almotriptan-Route 05

Synthetic Reference

Pradhan, Nitin Sharad Chandra; Purushotham, Vandanapu Loka Appala; Naik, Samir Jaivant; Sridharan, Ramasubramanian. Process for the preparation of almotriptan. Assignee Glenmark Pharmaceuticals Limited. 2006.

Almotriptan-Route 06

Synthetic Reference

Reddy, Manne Satyanarayana; Eswaraiah, Sajja; Reddy, Maramreddy Sahadeva. Improved process for the preparation of almotriptan and its pharmaceutically acceptable salts. Assignee MSN Laboratories Limited. 2012.

Almotriptan-Route 07

Synthetic Reference

Gore, Vinayak; Gadkar, Mahesh; Pokharkar, Kiran. Process for the preparation of almotriptan and its use in the treatment of migraine. Assignee Generics UK Limited, UK; Mylan Development Centre Private Limited. 2009.

Almotriptan-Route 08

Synthetic Reference

Ridvan, Ludek; Hruby, Petr; Stach, Jan; Radl, Stanislav; Voslar, Michal; Petrickova, Hana; Tisovska, Lucie; Zatopkova, Monika. Method for the preparation of high purity almotriptan. Assignee Zentiva, A.S. 2008.

Almotriptan-Route 09

Synthetic Reference

Xie, Yipeng; Peng, Xilin; Zhou, Weilan; Li, Yuanbo; Lan, Hai. Process for preparation of Almotriptan malate. Assignee Sichuan Hairong Pharmaceutical Co., Ltd., Yangtze River Pharmaceutical Group. 2012.
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