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Alosetron Hydrochloride

CAT# 317171
CAS# 122852-69-1
Alosetron is a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions. This agent is used to treat diarrhea-predominant irritable bowel syndrome in women only.
Synthetic Routes

Alosetron Hydrochloride-Route 01

Synthetic Reference

Pan, Li; Ji, Lei; Zheng, Yulin; Huang, Shaolin; Cheng, Maosheng. Improved process for the synthesis of Alosetron hydrochloride. Zhongguo Yaowu Huaxue Zazhi. Volume 12. Issue 4. Pages 222-224. 2002.

Alosetron Hydrochloride-Route 02

Synthetic Reference

Zhao, Huiqing; Jin, Yongsheng; Zhao, Qingjie; Sun, Qingyan; Wu, Qiuye. Synthesis of alosetron hydrochloride. Zhongguo Yiyao Gongye Zazhi. Volume 38. Issue 9. Pages 612-613. 2007.

Alosetron Hydrochloride-Route 03

Synthetic Reference

Coates, Ian Harold; North, Peter Charles; Oxford, Alexander William. Preparation of (imidazolylmethyl)oxoheterocycloindoles as 5-HT3 antagonists. Assignee Glaxo Group Ltd., UK. 1989.
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