Skip to content
Hodoodo.comHodoodo.com

MedKoo Biosciences

Sales@hodoodo.com, Tel: +1 919-636-5577; Fax: +1 919-980-4831

  • Menu
  • Login / Register
    • No products in the cart.

  • Structure Search
  • Cart

    No products in the cart.

  • Home
  • Products
  • Drug Synthesis
  • Ordering
    • How to Order
    • Terms & Conditions
    • Privacy Policy
  • Services
    • Custom Synthesis
    • Technical Support
  • About Us
  • Contact Us
  • Resources
    • Hodoodo chemical nomenclature
    • Organic chemistry acronyms
    • Chemistry abbreviations and acronyms
    • NMR peaks of solvent residue

Alvimopan

CAT# 326704
CAS# 156053-89-3
Alvimopan, also known as HSDB-7704 and LY246736, is a drug which behaves as a peripherally acting μ-opioid antagonist. With limited ability to cross the blood–brain barrier, many of the undesirable side-effects of the opioid agonists such as constipation are minimized without affecting analgesia or precipitating withdrawal. It was approved in 2008. Alvimopan is indicated in people to avoid postoperative ileus following partial large or small bowel resection with primary anastomosis. Alvimopan accelerates the gastrointestinal recovery period as defined by time to first bowel movement or flatus.
Synthetic Routes

Alvimopan route 1

Synthetic Reference

Ravilla, Lokesh; Venkata subba Naidu, N.; Dogra, Shalini; Umrao, Deepmala; Yadav, Prem N.; Biswas, Ansuman; Michael, Daliah; Sekar, Kanagaraj; Nagarajan, Kuppuswamy Journal of Medicinal Chemistry Volume 60 Issue 15 Pages 6733-6750 Journal 2017

Alvimopan route 2

Synthetic Reference

Werner, John A.; Cerbone, Louis R.; Frank, Scott A.; Ward, Jeffrey A.; Labib, Parviz; Tharp-Taylor, Roger W.; Ryan, C. W. Journal of Organic Chemistry Volume 61 Issue 2 Pages 587-97 Journal 1996

Alvimopan route 3

Synthetic Reference

Process for preparing alvimopan and their compositions containing opioid antagonists; Buehler, John D.; Assignee Adolor Corp., USA; 2007; Patent Information; Apr 26, 2007; WO 2007047935 A1

Alvimopan route 4

Synthetic Reference

Process for preparation of alvimopan and intermediates; Li, Liang; Tian, Qingsong; Wei, Wentao; Zhu, Hongxing; Yang, Shengli; Zhou, Xuefu; Qu, Hong; Wu, Minyi;Assignee Tianjin Taipu Medicine Science and Technology Development Co., Ltd., Peop. Rep. China; 2006; Patent Information; Sep 06, 2006; CN 827598 A

Alvimopan route 5

Synthetic Reference

2-[2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethylpiperidin-yl]methyl]-3-phenylacrylamido]acetic acid ester for preparing alvimopan, and the preparation method and application thereof; Zhang, Bo; Zhang, Yuchen; Zhang, Guisen; Ma, Yanqin; Yang, Xiangping; Assignee Jiangsu Nhwa Pharmaceutical Co., Ltd., Peop. Rep. China; 2012; Patent Information; Oct 03, 2012; CN 102702076 A
Support
  • Tel: +1 919-636-5577
  • Fax: +1 919-980-4831
  • Email: Sales@hodoodo.com

Products
  • Latest Products
  • Featured Product
  • Products Categories

Stay In Touch
MedKoo Biosciences @ 2021 All Rights Reserved. 网站设计VcuSoft
  • Home
  • Products
  • Drug Synthesis
  • Ordering
    • How to Order
    • Terms & Conditions
    • Privacy Policy
  • Services
    • Custom Synthesis
    • Technical Support
  • About Us
  • Contact Us
  • Resources
    • Hodoodo chemical nomenclature
    • Organic chemistry acronyms
    • Chemistry abbreviations and acronyms
    • NMR peaks of solvent residue
  • Newsletter
  • [wcas-search-form]

Login

Lost your password?

Register

Your personal data will be used to support your experience throughout this website, to manage access to your account, and for other purposes described in our privacy policy.