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Apomorphine Hydrochloride

CAT# 531003
CAS# 314-19-2 (HCl)
Apomorphine Hydrochloride, also known as APL-130277 and TAK-251, is a dopamine D2 agonist used for the treatment of Parkinson's disease. Apomorphine also promotes intraneuronal amyloid-β (Aβ) degradation and improves memory function in an Alzheimer's disease model. Protein levels of two types of serine-phosphorylated insulin receptor substrate-1 (IRS-1), pS616 and pS636/639, significantly decreased following Apomorphine treatment in the 13-month-old 3xTg-AD mice brain, suggesting improved brain insulin resistance.
Synthetic Routes

Apomorphine Hydrochloride-Route 01

Synthetic Reference

Csutoras, Csaba; Berenyi, Sandor; Neumeyer, John L. Investigation of the acid-catalyzed rearrangement of morphinans. Letters in Organic Chemistry. Volume 4. Issue 6. Pages 409-413. 2007.

Apomorphine Hydrochloride-Route 02

Synthetic Reference

Shi, Xiao-Xin; Ni, Feng; Shang, Hai-Xia; Yan, Ming-Le; Su, Jun-Quan. Racemization of (S)-(+)-10,11-dimethoxyaporphine and (S)-(+)-aporphine: Efficient preparations of (R)-(-)-apomorphine and (R)-(-)-aporphine via a recycle process of resolution. Tetrahedron: Asymmetry. Volume 17. Issue 15. Pages 2210-2215. 2006.
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