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Aripiprazole

CAT# 317201
CAS# 129722-12-9
Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is recommended and primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders, and irritability associated with autism. Aripiprazole is a quinoline derivate and atypical anti-psychotic agent. Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors.
Synthetic Routes

Aripiprazole-Route 01

Synthetic Reference

Shi, Hang; Babinski, David J.; Ritter, Tobias. Modular C-H Functionalization Cascade of Aryl Iodides. Journal of the American Chemical Society. Volume 137. Issue 11. Pages 3775-3778. 2015.

Aripiprazole-Route 02

Synthetic Reference

Bonacorsi, Samuel J., Jr.; Waller, Stephen C.; Rinehart, J. Kent. Synthesis of multi-labeled [14C]aripiprazole. Journal of Labelled Compounds & Radiopharmaceuticals. Department of Chemical Synthesis The Bristol-Myers Squibb Pharmaceutical Research Institute. Volume 49. Issue 1. Pages 1-9. 2006.

Aripiprazole-Route 03

Synthetic Reference

Pai, Nandini R.; Dubhashi, Deepnandan S.; Pusalkar, Deeptanshu. Substituted 3,4-dihydro-1H-quinolin-2-one derivatives as potential antidepressant, sedative and antiparkinson agents. International Journal of Pharmaceutical Sciences Review and Research. Department of Organic Chemistry. D.G. Ruparel College. Volume 5. Issue 2. Pages 124-131. 2010.

Aripiprazole-Route 04

Synthetic Reference

Kowalski, Piotr; Jaskowska, Jolanta. An Efficient Synthesis of Aripiprazole, Buspirone and NAN-190 by the Reductive Alkylation of Amines Procedure. Archiv der Pharmazie (Weinheim, Germany). Institute of Organic Chemistry and Technology, Cracow University of Technology. Volume 345. Issue 1. Pages 81-85. Journal. 2012.

Aripiprazole-Route 05

Synthetic Reference

Yang, Li; Shi, Lijun; Xing, Qi; Huang, Kuo-Wei; Xia, Chungu; Li, Fuwei. Enabling CO Insertion into o-Nitrostyrenes beyond Reduction for Selective Access to Indolin-2-one and Dihydroquinolin-2-one Derivatives. ACS Catalysis. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP). Chinese Academy of Sciences. Volume 8. Issue 11. Pages 10340-10348. 2018.

Aripiprazole-Route 06

Synthetic Reference

Zhang, Zhaozhen; Zhu, Lihui; Pang, Wen; Zhu, Yidong; Hou, Zijie. Synthesis of aripiprazole. Zhongguo Yiyao Gongye Zazhi. Qilu Pharmaceutical Co., Ltd. Volume 40. Issue 1. Pages 6-8. 2009.

Aripiprazole-Route 07

Synthetic Reference

Liu, Xiu-jie; Wang, Ti-ti; Zhong, Yong-liang; Wang, Xiao. Synthesis of antipsychotic aripiprazole. Shenyang Yaoke Daxue Xuebao. The College of Chemistry and Chemical Engineering, Tianjin University of Technology. Volume 30. Issue 4. Pages 253-255. 2013.

Aripiprazole-Route 08

Synthetic Reference

Kollapudi, Chandra Babu; Gutta, Madhusudhan; Reguri, Buchi Reddy. Green methodologies in organic synthesis: microwave-assisted study on carbostyril derivatives under phase transfer catalysis. Heterocyclic Letters. Centre for Pharmaceutical Sciences, JNT University. Volume 5. Issue 2. Pages 213-221. 2015.

Aripiprazole-Route 09

Synthetic Reference

Czarnik, Anthony W. Deuterium-enriched aripiprazole for treatment of schizophrenia. Assignee Protia, LLC. 2008.

Aripiprazole-Route 10

Synthetic Reference

Du, Xiaochun; Qin, Xinrong; Cai, Fubo; Xu, Guanbing; Li, Wen. A process for preparing aripiprazole and its intermediates. Assignee Chengdu Kanghong Pharmaceutical Group Co., Ltd.2009.
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