Articaine HCl is a local anesthetic. Articaine HCl blocks nerve conduction by reversibly binding to the alpha-subunit of the voltage-gated sodium channels within the inner cavity of the nerve.
Articaine hydrochloride-Route 01
Duan, Yabo; Zhang, Guohong; Li, Yi; Fang, Gang; Wu, Liping; Cui, Jianmei; Wu, Song. Facile synthesis of articaine hydrochloride. Zhongguo Yaowu Huaxue Zazhi. Institute of Materia Medica. Peking Union Medical College and Chinese Academy of Medical Sciences. Volume 14. Issue 2. Pages 109-111. 2004.
Articaine hydrochloride-Route 02
Savel'ev, E. A.; Semenov, P. A.; Kovalevskaya, A. L. Method for preparing 4-methyl-3-[2-(n-propylamino)propionylamino]thiophene-2-carboxylic acid methyl ether hydrochloride. 2013.
Articaine hydrochloride-Route 03
Kadushkin, A. V.; Trofimkin, Yu. I.; Granik, V. G. Method for the manufacture of methyl 4-methyl-3-[2-(1-propylamino)propionylamino]thiophene-2-carboxylate hydrochloride which does not require vacuum distillation purification. Assignee Gosudarstvennyi Nauchnyi Tsentr Rossiiskoi Federatsii "NIOPIK".2002.