Alcaftadine

CAT#: H314209

CAS#: 147084-10-4

Description: Alcaftadine is used to prevent eye irritation brought on by allergic conjunctivitis. It is a H1 histamine receptor antagonist. It was approved by the U.S. Food and Drug Administration in 2010 under the trade name Lastacaft. Alcaftadine is an antagonist at three of the histamine receptors (1, 2 and 4). The main indication for Alcaftadine is for prevention of allergic conjunctivitis. By blocking these four receptors, Alcaftadine has been shown to significantly reduce the effects of allergens.

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Synthetic Routes

Alcaftadine - Synthetic Route 1

Alcaftadine route01

Synthetic reference

Ponnaiah, Ravi; Hashmi, Arshad Moosa; Neela, Praveen Kumar; Seemala, Dhanunjaya Naidu; Mokka, Raviteja; Lahoti, Anandkumar Madanlal; Deepthi, V. P. S. S.; Saradhi, G. Srinivas Pardha. A process for the preparation of alcaftadine (Assignee Neuland Laboratories Limited, India). 2014 Patent Information. Jun 05, 2014. WO 2014083571 A1

Alcaftadine - Synthetic Route 2

Alcaftadine route02

Synthetic reference

Process for the preparation of 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-5h-imidazo[2, 1-b][3]benzazepine-3-carboxaldehyde and it's novel polymorph; Rajan, Srinivasan Thirumalai; Eswaraiah, Sajja; Sarma, Peri Seetha Rama; Assignee MSN Laboratories Private Limited, India; 2015; Patent Information; Sep 18, 2015; IN 2014CH01257 A

Alcaftadine - Synthetic Route 3

Alcaftadine route03

Synthetic reference

Novel and improved process for the preparation of alcaftadine; Mallela, Sambhu Prasad Sarma; Lakkoju, Chakrapani; Buchepalli, Mysura Reddy; Dubakula, Yakaiah; Pasunuti, Anil; Assignee Vivimed Labs Ltd., India; 2016; Patent Information; Feb 05, 2016; IN 2014CH03056 A

Alcaftadine - Synthetic Route 4

Alcaftadine route04

Synthetic reference

Synthesis of Alcaftadine intermediates and Alcaftadine by introducing hydroxymethyl from (1H-imidazol-5-yl) methanol raw material; Li, Longxia; Liu, Bao; Wu, Kai; Bao, Jinyuan; Jiang, Yuwei; Zhang, Xiaoqing; Assignee Nanjing Huawei Pharmaceutical Science and Technology Development Co., Ltd., Peop. Rep. China; 2015; Patent Information; Aug 26, 2015; CN 104860888 A

Alcaftadine - Synthetic Route 5

Alcaftadine route05

Synthetic reference

Methods for the preparation of alcaftadine; Bonde-Larsen, Antonio Lorente; Retuerto, Jesus Miguel Iglesias; Nieto, Franciso Javier Gallo; Gil, Juan Jose Ferreiro; Assignee Crystal Pharma S.A.U., Spain; 2014; Patent Information; Oct 02, 2014; WO 2014154620 A1