Ambrisentan

CAT#: H326690

CAS#: 177036-94-1


Description: Ambrisentan, also known as BSF-208075 and LU-208075, is a drug indicated for use in the treatment of pulmonary hypertension. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2). Ambrisentan was approved by the U.S. Food and Drug Administration (FDA) and European Medicines Agency, and designated an orphan drug, for the treatment of pulmonary hypertension.

img

Synthetic Routes

Ambrisentan - Synthetic Route 1

Ambrisentan route01

Synthetic reference

Isolation, identification, characterization, synthesis and quality control strategy of new process-related impurities in ambrisentan; Feng, Wei-Dong; Zhuo, Song-Ming; Zhang, Fu-Li Journal of Pharmaceutical and Biomedical Analysis Volume 165 Pages 325-337 Journal; 2019

Ambrisentan - Synthetic Route 2

Ambrisentan route02

Synthetic reference

Multistep process for preparation of ambrisentan and darusentan; Satyanarayana Reddy, Manne; Nagaraju, Chakilam; Ramprasad, Achampeta Kodanda; Assignee MSN Laboratories Limited, India 2010; Patent Information; Jun 24, 2010; WO 2010070658 A2

Ambrisentan - Synthetic Route 3

Ambrisentan route03

Synthetic reference

Study on the synthesis of ambrisentan; Li, Xiao-gang; Yingyong Huagong; Volume 43; Issue 9; Pages 1675-1678; Journal; 2014

Ambrisentan - Synthetic Route 4

Ambrisentan route04

Synthetic reference

Process for preparation of Ambrisentan and intermediates thereof; Lin, Feng; Zhu, Xiaofeng; Chen, Jianli; Xu, Qiulong; Assignee Shanghai Institute of Pharmaceutical Industry, Peop. Rep. China; 2013; Patent Information; Nov 21, 2013; WO 2013170778 A1

Ambrisentan - Synthetic Route 5

Ambrisentan route05

Synthetic reference

Method for preparation of (S)-2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid and ambrisentan via optical resolution of its racemate using commercially available (S)-(+)-1,2,3,4-tetrahydro-1-naphthylamine; Amagasa, Katsuaki; Oonami, Toshihiko; Assignee Toa Eiyo, Ltd., Japan, 2017; Patent Information; Jul 27, 2017; JP 2017128528 A

Ambrisentan - Synthetic Route 6

Ambrisentan route06

Synthetic reference

LC-MS/MS characterization of forced degradation products of ambrisentan: development and validation of a stability-indicating RP-HPLC method; Ramisetti, Nageswara Rao; Kuntamukkala, Ramakrishna; New Journal of Chemistry; Volume 38; Issue 7; Pages 3050-3061; Journal; 2014