Alogliptin

CAT#: H573693

CAS#: 850649-61-5

Description: Alogliptin is a DPP-4 inhibitor used for the treatment of Type 2 diabetes. Like other members of the gliptin class, it causes little or no weight gain, exhibits relatively little risk of causing hypoglycemia, and exhibits relatively modest glucose-lowering activity. Alogliptin and other gliptins are commonly used in combination with metformin in patients whose diabetes cannot adequately be controlled with metformin alone.

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Synthetic Routes

Alogliptin - Synthetic Route 1

Alogliptin route01

Synthetic reference

Ji, Jianjian; Chen, Caiyou; Cai, Jiayu; Wang, Xinrui; Zhang, Kai; Shi, Liyang; Lv, Hui; Zhang, Xumu. Highly enantioselective synthesis of non-natural aliphatic α-amino acids via asymmetric hydrogenation. Organic & Biomolecular Chemistry. Volume 13. Issue 28. Pages 7624-7627. Journal; Online Computer File. (2015).

Alogliptin - Synthetic Route 2

Alogliptin route02

Synthetic reference

Feng, Jun; Zhang, Zhiyuan; Wallace, Michael B.; Stafford, Jeffrey A.; Kaldor, Stephen W.; Kassel, Daniel B.; Navre, Marc; Shi, Lihong; Skene, Robert J.; Asakawa, Tomoko; Takeuchi, Koji; Xu, Rongda; Webb, David R.; Gwaltney, Stephen L., II. Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV. Journal of Medicinal Chemistry. Volume 50. Issue 10. Pages 2297-2300. Journal. (2007).

Alogliptin - Synthetic Route 3

Alogliptin route03

Synthetic reference

Vadali, Lakshmana Rao; Dasari, Srinivasa Rao; Manukonda, Seshadri Rao; Ponduri, Rajasekhar. Process for preparation of alogliptin. Assignee Mylan Laboratories Ltd., India. WO 2015092739. (2015).

Alogliptin - Synthetic Route 4

Alogliptin route04

Synthetic reference

Lixin, Juanzi; Li, Jianzhi; Wang, Xun; Li, Yonggang; Chi, Wangzhou; Shen, Xiaoliang; Liu, Hai; Gao, Yan; Lv, Xinghong. Process for preparation of alogliptin. Assignee Shanghai Tianci Biological Valley Engineering Co., Ltd., Peop. Rep. China. CN 104447685. (2015).

Alogliptin - Synthetic Route 5

Alogliptin route05

Synthetic reference

Yamada, Masatoshi; Hirano, Sayuri; Tsuruoka, Ryoji; Yamano, Mitsuhisa. Preparation of optically active piperidinecarboxamides and their dioxotetrahydropyrimidine derivatives. Assignee Takeda Pharmaceutical Company Limited, Japan. WO 2015137496. (2015).