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Belinostat

CAT#: H200460

CAS#: 866323-14-0

Description: Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. Belinostat was approved in 2014 for relapsed or refractory peripheral T-cell lymphoma.

Synthetic Routes

Belinostat - Synthetic Route 1

Synthetic reference

Bao, Xuefei; Song, Dake; Qiao, Xuejun; Zhao, Xuan; Chen, Guoliang. The development of an effective synthetic route of belinostat. Organic Process Research & Development. Volume 20. Issue 8. Pages 1482-1488. Journal; Online Computer File. (2016).

Belinostat - Synthetic Route 2

Synthetic reference

Finn, Paul W.; Bandara, Morwena; Butcher, Chris; Finn, Angela; Hollinshead, Ruth; Khan, Nagma; Law, Norman; Murthy, Sreenivasa; Romero, Rosario; Watkins, Clare; Andrianov, Victor; Bokaldere, Rasma M.; Dikovska, Klara; Gailite, Vija; Loza, Einars; Piskunova, Irina; Starchenkov, Igor; Vorona, Maxim; Kalvinsh, Ivars. . Novel sulfonamide derivatives as inhibitors of histone deacetylase. Helvetica Chimica Acta. Volume 88. Issue 7. Pages 1630-1657. Journal. (2005).

Belinostat - Synthetic Route 3

Synthetic reference

Qian, Jianbin; Zhang, Guangming; Qin, Huaiwei; Zhu, Yong; Xiao, Yang. Method for synthesizing belinostat. Assignee Shenzhen Main Luck Pharmaceuticals Inc., Peop. Rep. China. CN 102786448. (2012).

Belinostat - Synthetic Route 4

Synthetic reference

Pullagurla, Manik Reddy; Kumar, Mecheril Valsan Nanda; Pitta, Bhaskar Reddy; Rangisetty, Jagadeesh Babu. Novel process for the preparation of Belinostat. Assignee Biophore India Pharmaceutials Private Limited, India. IN 201641017008. (2017).

Belinostat - Synthetic Route 5

Synthetic reference

Wang, Qingqiu; Luo, Jin; Cao, Yan; Zhang, Li; Li, Changxi; Yuan, Qing. A process for preparing belinostat cis-isomer. Assignee Shenzhen Main Luck Pharmaceuticals Inc., Peop. Rep. China. CN 105367455. (2016).