WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525082
CAS#: 133920-65-7
Description: FR 121196 is a potential antidementia drug. It ameliorates the impaired memory of rat in the Morris water maze.
Hodoodo Cat#: H525082
Name: FR 121196
CAS#: 133920-65-7
Chemical Formula: C12H16FN3O3S
Exact Mass: 301.09
Molecular Weight: 301.340
Elemental Analysis: C, 47.83; H, 5.35; F, 6.30; N, 13.94; O, 15.93; S, 10.64
This product is not in stock, which may be available by custom synthesis.
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Synonym: FR 121196; FR 121196; FR 121196.
IUPAC/Chemical Name: Piperazine, 1-acetyl-4-(((4-fluorophenyl)sulfonyl)amino)-
InChi Key: PZQKOVUNWPDCCQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H16FN3O3S/c1-10(17)15-6-8-16(9-7-15)14-20(18,19)12-4-2-11(13)3-5-12/h2-5,14H,6-9H2,1H3
SMILES Code: N1(CCN(CC1)NS(=O)(=O)c1ccc(cc1)F)C(=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 301.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Maeda N, Matsuoka N, Yamazaki M, Yamaguchi I. Involvement of raphe-hippocampal serotonergic and septo-hippocampal cholinergic mechanisms in the penile erection induced by FR121196, a putative cognitive enhancer. Jpn J Pharmacol. 1995 May;68(1):85-94. PubMed PMID: 7494387.
2: Yamazaki M, Matsuoka N, Maeda N, Kuratani K, Ohkubo Y, Yamaguchi I. FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze. J Pharmacol Exp Ther. 1995 Jan;272(1):256-63. PubMed PMID: 7815340.
3: Matsuoka N, Maeda N, Yamaguchi I, Satoh M. Possible involvement of brain somatostatin in the memory formation of rats and the cognitive enhancing action of FR121196 in passive avoidance task. Brain Res. 1994 Apr 11;642(1-2):11-9. PubMed PMID: 7913390.
4: Maeda N, Matsuoka N, Yamazaki M, Arakawa H, Ohkubo Y, Yamaguchi I. A screening concept based on a hypothesis led to the development of a putative cognitive enhancer that stimulates penile erection. Jpn J Pharmacol. 1994 Mar;64(3):147-53. PubMed PMID: 8022116.
5: Matsuoka N, Yamaguchi I, Satoh M. Role of somatostatin in the augmentation of hippocampal long-term potentiation by FR121196, a putative cognitive enhancer. Eur J Pharmacol. 1993 Sep 7;241(1):27-34. PubMed PMID: 7901036.
6: Matsuoka N, Maeda N, Yamazaki M, Ohkubo Y, Yamaguchi I. Effect of FR121196, a novel cognitive enhancer, on the memory impairment of rats in passive avoidance and radial arm maze tasks. J Pharmacol Exp Ther. 1992 Nov;263(2):436-44. PubMed PMID: 1432682.
