WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H406785
CAS#: 931078-17-0
Description: CPI-905 is a potent and selective EZH2 inhibitor (IC50 = 39.5 nM). The histone lysine methyltransferase (MT) Enhancer of Zeste Homolog 2 (EZH2) is considered an oncogenic driver in a subset of germinal center B-celllike diffuse large B cell lymphoma (GCB-DLBCL) and follicular lymphoma due to the presence of recurrent, monoallelic mutations in the EZH2 catalytic domain. .
Hodoodo Cat#: H406785
Name: CPI-905
CAS#: 931078-17-0
Chemical Formula: C18H20N2O5
Exact Mass: 344.14
Molecular Weight: 344.367
Elemental Analysis: C, 62.78; H, 5.85; N, 8.13; O, 23.23
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Synonym: CPI-905; CPI 905; CPI905.
IUPAC/Chemical Name: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-8-methoxy-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide
InChi Key: KMBHNILDGJPMCU-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H20N2O5/c1-10-6-11(2)20-18(22)13(10)9-19-17(21)12-7-14(23-3)16-15(8-12)24-4-5-25-16/h6-8H,4-5,9H2,1-3H3,(H,19,21)(H,20,22)
SMILES Code: CC1=CC(C)=C(CNC(C2=CC(OCCO3)=C3C(OC)=C2)=O)C(N1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 344.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Bradley WD, Arora S, Busby J, Balasubramanian S, Gehling VS, Nasveschuk CG,
Vaswani RG, Yuan CC, Hatton C, Zhao F, Williamson KE, Iyer P, Méndez J, Campbell
R, Cantone N, Garapaty-Rao S, Audia JE, Cook AS, Dakin LA, Albrecht BK, Harmange
JC, Daniels DL, Cummings RT, Bryant BM, Normant E, Trojer P. EZH2 inhibitor
efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27
monomethylation. Chem Biol. 2014 Nov 20;21(11):1463-75. doi:
10.1016/j.chembiol.2014.09.017. PubMed PMID: 25457180.