WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526779
CAS#: 876708-03-1
Description: RO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM). RO-9187 is an excellent substrate for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 is a new class of antiviral nucleosides with promising preclinical properties as potential medicines for the treatment of HCV infection.
Hodoodo Cat#: H526779
Name: RO-9187
CAS#: 876708-03-1
Chemical Formula: C9H12N6O5
Exact Mass: 284.09
Molecular Weight: 284.232
Elemental Analysis: C, 38.03; H, 4.26; N, 29.57; O, 28.14
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: RO-9187; RO 9187; RO9187.
IUPAC/Chemical Name: 4-amino-1-[(2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
InChi Key: ODLGMSQBFONGNG-XZMZPDFPSA-N
InChi Code: InChI=1S/C9H12N6O5/c10-4-1-2-15(8(19)12-4)7-5(17)6(18)9(3-16,20-7)13-14-11/h1-2,5-7,16-18H,3H2,(H2,10,12,19)/t5-,6-,7+,9+/m0/s1
SMILES Code: O=C1N=C(N)C=CN1[C@@H]2O[C@@](CO)(N=[N+]=[N-])[C@@H](O)[C@@H]2O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 284.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Klumpp K, Kalayanov G, Ma H, Le Pogam S, Leveque V, Jiang WR, Inocencio N, De
Witte A, Rajyaguru S, Tai E, Chanda S, Irwin MR, Sund C, Winqist A, Maltseva T,
Eriksson S, Usova E, Smith M, Alker A, Najera I, Cammack N, Martin JA, Johansson
NG, Smith DB. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors
of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. J
Biol Chem. 2008 Jan 25;283(4):2167-75. Epub 2007 Nov 14. PubMed PMID: 18003608.