WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525779
CAS#: 124265-89-0
Description: Omaciclovir, also known as ABT-091 and H2G, is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HSV infection. Omaciclovir is selectively phosphorylated by viral thymidine kinase to its monophosphate form and is further modified to a triphosphate, which is an inhibitor of VZV DNA polymerase.
Hodoodo Cat#: H525779
Name: Omaciclovir
CAS#: 124265-89-0
Chemical Formula: C10H15N5O3
Exact Mass: 253.12
Molecular Weight: 253.258
Elemental Analysis: C, 47.42; H, 5.97; N, 27.65; O, 18.95
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: ABT-091; ABT091; ABT 091; H2G; H 2G; (-)-2HM-HBG; A-182091; 2HMHBG; Omaciclovir
IUPAC/Chemical Name: (R)-2-amino-9-(4-hydroxy-2-(hydroxymethyl)butyl)-1H-purin-6(9H)-one
InChi Key: SCBFBAWJWLXVHS-ZCFIWIBFSA-N
InChi Code: InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)3-6(4-17)1-2-16/h5-6,16-17H,1-4H2,(H3,11,13,14,18)/t6-/m1/s1
SMILES Code: O=C1NC(N)=NC2=C1N=CN2C[C@H](CO)CCO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 253.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Bonnafous P, Agut H. Activity of H2G on human herpesvirus-6B strains either
sensitive or resistant to ganciclovir. J Clin Virol. 2010 Jun;48(2):153-4. doi:
10.1016/j.jcv.2010.03.019. PubMed PMID: 20395169.
2: Yao K, Hoest C, Rashti F, Schott TC, Jacobson S. Effect of
(r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human
herpesvirus-6B infected cells. J Clin Virol. 2009 Sep;46(1):10-4. doi:
10.1016/j.jcv.2009.05.014. PubMed PMID: 19524486.
3: Neyts J, Andrei G, De Clercq E. The antiherpesvirus activity of H2G
[(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the
novel immunosuppressive agent mycophenolate mofetil. Antimicrob Agents Chemother.
1998 Dec;42(12):3285-9. PubMed PMID: 9835529; PubMed Central PMCID: PMC106037.