WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525450
CAS#: 60628-98-0
Description: Lombazole is an antimicrobial agent of the imidazole class.
Hodoodo Cat#: H525450
Name: Lombazole
CAS#: 60628-98-0
Chemical Formula: C22H17ClN2
Exact Mass: 344.11
Molecular Weight: 344.840
Elemental Analysis: C, 76.63; H, 4.97; Cl, 10.28; N, 8.12
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Synonym: Lombazole; Bay h 6020; EINECS 262-337-1; Lombazole; Lombazolum.
IUPAC/Chemical Name: 1-([1,1'-biphenyl]-4-yl(2-chlorophenyl)methyl)-1H-imidazole
InChi Key: DALSNPRWUFOYDT-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H17ClN2/c23-21-9-5-4-8-20(21)22(25-15-14-24-16-25)19-12-10-18(11-13-19)17-6-2-1-3-7-17/h1-16,22H
SMILES Code: ClC1=CC=CC=C1C(N2C=CN=C2)C3=CC=C(C4=CC=CC=C4)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 344.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Barug D, Bastiaanse HB, van Rossum JM, Kerkenaar A. Action of lombazole, and inhibitor of fungal ergosterol biosynthesis, on Staphylococcus epidermidis. Antimicrob Agents Chemother. 1986 Aug;30(2):238-44. PubMed PMID: 3532943; PubMed Central PMCID: PMC180526.
2: Barug D, de Groot K. Effect of the imidazole derivative lombazole on the ultrastructure of Staphylococcus epidermidis and Candida albicans. Antimicrob Agents Chemother. 1985 Nov;28(5):643-7. PubMed PMID: 3911878; PubMed Central PMCID: PMC176349.