WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526808
CAS#: 41332-24-5
Description: NP-118809 is a N-type calcium channel blocker. NP-118809 exhibits both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain. NP118809 further exhibits a number of favorable preclinical characteristics as they relate to overall pharmacokinetics and minimal off-target activity including the hERG potassium channel.
Hodoodo Cat#: H526808
Name: NP118809
CAS#: 41332-24-5
Chemical Formula: C32H32N2O
Exact Mass: 460.25
Molecular Weight: 460.621
Elemental Analysis: C, 83.44; H, 7.00; N, 6.08; O, 3.47
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Synonym: 39-1B4; NP 118809; NP-118809; NP118809; Z160; Z160; Z160.
IUPAC/Chemical Name: 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one
InChi Key: VCPMZDWBEWTGNW-UHFFFAOYSA-N
InChi Code: InChI=1S/C32H32N2O/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30,32H,21-25H2
SMILES Code: O=C(N1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)CC(C4=CC=CC=C4)C5=CC=CC=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 460.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Pajouhesh H, Feng ZP, Ding Y, Zhang L, Pajouhesh H, Morrison JL, Belardetti F,
Tringham E, Simonson E, Vanderah TW, Porreca F, Zamponi GW, Mitscher LA, Snutch
TP. Structure-activity relationships of diphenylpiperazine N-type calcium channel
inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1378-83. doi:
10.1016/j.bmcl.2010.01.008. Epub 2010 Jan 7. PubMed PMID: 20117000.
2: Zamponi GW, Feng ZP, Zhang L, Pajouhesh H, Ding Y, Belardetti F, Pajouhesh H,
Dolphin D, Mitscher LA, Snutch TP. Scaffold-based design and synthesis of potent
N-type calcium channel blockers. Bioorg Med Chem Lett. 2009 Nov
15;19(22):6467-72. doi: 10.1016/j.bmcl.2009.09.008. Epub 2009 Sep 11. PubMed
PMID: 19815411.