WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130004
CAS#: N/A
Description: E11K4K10 is an antimicrobial peptide against the antimicrobial-resistance crisis and has been shown to have an excellent therapeutic effect on a mouse model of pulmonary bacterial infection.
Hodoodo Cat#: H130004
Name: E11K4K10
CAS#: N/A
Chemical Formula: C75H131N17O15
Exact Mass: 1,510.00
Molecular Weight: 1,510.980
Elemental Analysis: C, 59.62; H, 8.74; N, 15.76; O, 15.88
This product is not in stock, which may be available by custom synthesis.
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Synonym: E11K4K10;
IUPAC/Chemical Name: Phe-Leu-Pro-Lys-Val-Ala-Lys-Leu-Leu-Lys-Glu-Leu-Leu-NH2
InChi Key: ZSKCXPPAVFPFSQ-BQGXDPKVSA-N
InChi Code: InChI=1S/C75H131N17O15/c1-42(2)36-55(63(80)95)86-71(103)57(38-44(5)6)88-68(100)54(30-31-61(93)94)84-66(98)52(27-18-21-33-77)83-70(102)56(37-43(3)4)89-72(104)58(39-45(7)8)87-67(99)51(26-17-20-32-76)82-64(96)48(13)81-74(106)62(47(11)12)91-69(101)53(28-19-22-34-78)85-73(105)60-29-23-35-92(60)75(107)59(40-46(9)10)90-65(97)50(79)41-49-24-15-14-16-25-49/h14-16,24-25,42-48,50-60,62H,17-23,26-41,76-79H2,1-13H3,(H2,80,95)(H,81,106)(H,82,96)(H,83,102)(H,84,98)(H,85,105)(H,86,103)(H,87,99)(H,88,100)(H,89,104)(H,90,97)(H,91,101)(H,93,94)/t48-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,62-/m0/s1
SMILES Code: O=C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,510.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Ouyang X, Li B, Yang Y, Ba Z, Zhang J, Zhang T, Chang L, Zhang F, Zhang Y, Liu H, Gou S, Ni J. Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies. J Med Chem. 2022 Oct 27;65(20):13833-13851. doi: 10.1021/acs.jmedchem.2c01076. Epub 2022 Sep 23. PMID: 36148510.