WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122724
CAS#: 1815600-11-3
Description: T1742, also known as 4E 1RCat, is an autophagy Inhibitor by disrupting the Protein−Protein Interactions Involving Autophagy-Related 5. T1742 blocked the ATG5−ATG16L1 and ATG5−TECAIR interactions in the in vitro binding assay (IC50 = 1−2 μM) and also exhibited autophagy inhibition in cellular assays.
Hodoodo Cat#: H122724
Name: T1742
CAS#: 1815600-11-3
Chemical Formula: C28H18N2O6
Exact Mass: 478.12
Molecular Weight: 478.460
Elemental Analysis: C, 70.29; H, 3.79; N, 5.86; O, 20.06
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Synonym: T1742; T-1742; T 1742; 4E 1RCat;
IUPAC/Chemical Name: (E)-4-(3-((5-(4-nitrophenyl)furan-2-yl)methylene)-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl)benzoic acid
InChi Key: BBQRBOIMSKMFFO-LTGZKZEYSA-N
InChi Code: InChI=1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16+
SMILES Code: O=C1N(C2=CC=C(C(O)=O)C=C2)C(C3=CC=CC=C3)=C/C1=C\C(O4)=CC=C4C5=CC=C([N+]([O-])=O)C=C5
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 478.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Xiang H, Liu R, Zhang X, An R, Zhou M, Tan C, Li Q, Su M, Guo C, Zhou L, Li Y, Wang R. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein-Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 7. doi: 10.1021/acs.jmedchem.2c01233. Epub ahead of print. PMID: 36749313.