WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526814
CAS#: 1356354-09-0
Description: T-3364366 is a potent, reversible, slow-binding D5D inhibitor with D5D Ki < 2.7 nM and a dissociation half-life in excess of 2.0 h. The long residence time was confirmed in cellular washout assays. Delta-5 desaturase (D5D) catalyzes the conversion from dihomo-gamma linoleic acid (DGLA) to arachidonic acid (AA). DGLA and AA are common precursors of anti- and pro-inflammatory eicosanoids, respectively, making D5D an attractive drug target for inflammatory-related diseases.
Hodoodo Cat#: H526814
Name: T-3364366
CAS#: 1356354-09-0
Chemical Formula: C18H16F3N3O3S2
Exact Mass: 443.06
Molecular Weight: 443.459
Elemental Analysis: C, 48.75; H, 3.64; F, 12.85; N, 9.48; O, 10.82; S, 14.46
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Synonym: T-3364366, T 3364366, T3364366
IUPAC/Chemical Name: N-(2-((4-oxo-3-(4-(2,2,2-trifluoroethoxy)phenyl)-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl)thio)ethyl)acetamide
InChi Key: BVRXQXNVDLUWMV-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H16F3N3O3S2/c1-11(25)22-6-7-29-17-23-15-9-28-8-14(15)16(26)24(17)12-2-4-13(5-3-12)27-10-18(19,20)21/h2-5,8-9H,6-7,10H2,1H3,(H,22,25)
SMILES Code: O=C1N(C2=CC=C(OCC(F)(F)F)C=C2)C(SCCNC(C)=O)=NC3=CSC=C31
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 443.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time Ikuo Miyahisa, Hideo Suzuki, Atsushi Mizukami, Yukiya Tanaka, Midori Ono, Mark S. Hixon, and Junji Matsui Publication Date (Web): August 10, 2016 (Letter) DOI: 10.1021/acsmedchemlett.6b00241