WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525541
CAS#: 182564-47-2
Description: LY 302148 is a 5-HT1F receptor agonist that inhibits neurogenic dural inflammation in guinea pigs. LY 302148 has potential for migraine therapeutics.
Hodoodo Cat#: H525541
Name: LY 302148
CAS#: 182564-47-2
Chemical Formula: C19H23FN4
Exact Mass: 326.19
Molecular Weight: 326.420
Elemental Analysis: C, 69.91; H, 7.10; F, 5.82; N, 17.16
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Synonym: LY 302148; LY-302148; LY302148.
IUPAC/Chemical Name: 1H-Indole, 5-fluoro-3-(1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-4-piperidinyl)-
InChi Key: RFIDURCIAHBFRJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H23FN4/c1-23-13-14(11-22-23)4-7-24-8-5-15(6-9-24)18-12-21-19-3-2-16(20)10-17(18)19/h2-3,10-13,15,21H,4-9H2,1H3
SMILES Code: CN1N=CC(CCN2CCC(C3=CNC4=C3C=C(F)C=C4)CC2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 326.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Johnson KW, Schaus JM, Durkin MM, Audia JE, Kaldor SW, Flaugh ME, Adham N, Zgombick JM, Cohen ML, Branchek TA, Phebus LA. 5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs. Neuroreport. 1997 Jul 7;8(9-10):2237-40. PubMed PMID: 9243618.