WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H207191

CAS#: 2607829-38-7

Description: BDTX-1535 is a potent, selective, brain penetrant and irreversible MasterKey inhibitor of EGFR mutations that expressed in glioblastoma multiforme (GBM) and intrinsic and acquired resistance EGFR mutations in non-small cell lung cancer (NSCLC). BDTX-1535 selectively targets, irreversibly binds to, and inhibits the activity of various EGFR alterations and mutations, including certain intrinsic and acquired resistance mutations. This prevents EGFR-mediated signaling in susceptible tumor cells. BDTX-1535 may mitigate resistance to osimertinib, the standard of care for EGFR-mutant non-small cell lung cancer. It could also potentially treat central nervous system metastases, having shown preclinical efficacy in glioblastoma.

Chemical Structure

CAS# 2607829-38-7

Theoretical Analysis

Hodoodo Cat#: H207191
Name: BDTX-1535
CAS#: 2607829-38-7
Chemical Formula: C30H30ClFN6O2
Exact Mass: 560.2103
Molecular Weight: 561.0584
Elemental Analysis: C, 64.22; H, 5.39; Cl, 6.32; F, 3.39; N, 14.98; O, 5.70

Price and Availability

Size Price Availability Quantity
1.0mg USD 150.0 Ready to ship
5.0mg USD 450.0 Ready to ship
10.0mg USD 750.0 Ready to ship
25.0mg USD 1350.0 Ready to ship
50.0mg USD 2250.0 Ready to ship
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Synonym: BDTX-1535; BDTX 1535; BDTX1535;

IUPAC/Chemical Name: (2E)-N-[4-[(3-Chloro-2-fluorophenyl)amino]-7-[2-[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-1-yl]ethynyl]-6-quinazolinyl]-4-(4-morpholinyl)-2-butenamide


InChi Code: InChI=1S/C30H30ClFN6O2/c1-37-17-21-16-30(21,18-37)8-7-20-14-26-22(29(34-19-33-26)36-24-5-2-4-23(31)28(24)32)15-25(20)35-27(39)6-3-9-38-10-12-40-13-11-38/h2-6,14-15,19,21H,9-13,16-18H2,1H3,(H,35,39)(H,33,34,36)/b6-3+/t21-,30+/m1/s1

SMILES Code: O=C(NC1=CC2=C(NC3=CC=CC(Cl)=C3F)N=CN=C2C=C1C#C[C@]45CN(C)C[C@@]4([H])C5)/C=C/CN6CCOCC6

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001


Preparing Stock Solutions

The following data is based on the product molecular weight 561.0584 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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BDTX-1535 Goes after Osimertinib Resistance. Cancer Discov. 2021 Dec 1;11(12):2952-2953. doi: 10.1158/2159-8290.CD-NB2021-0395. PMID: 34702733.